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Novel powerful dizziness-relieving capsule and preparation method thereof

A powerful, capsule-based technology, applied in capsule delivery, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of content moisture absorption, cost increase, poor fluidity, etc., to reduce hygroscopicity, improve fluidity, and ensure The effect of curative effect

Active Publication Date: 2020-08-07
SHAANXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This preparation method needs to strictly control the temperature and humidity of the production and storage environment in order to avoid moisture absorption, adhesion and poor fluidity of the contents.
Che Rui, Moisture-proof excipients used to improve the hygroscopicity of Qiangli Dingxuan capsule raw material (extract powder)[D]. Hygroscopicity, but whether it is controlling the production environment or adding excipients, it will increase the cost, and adding excipients also has the risk of affecting the efficacy of the drug

Method used

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  • Novel powerful dizziness-relieving capsule and preparation method thereof
  • Novel powerful dizziness-relieving capsule and preparation method thereof
  • Novel powerful dizziness-relieving capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 Preparation of strong Dingxuan capsule raw material of the present invention

[0030] Formula: Gastrodia elata 273g, Eucommia 273g, wild chrysanthemum 670g, Eucommia leaves 839g, Chuanxiong 335g;

[0031] Preparation:

[0032] 1) Get 136g Gastrodia elata, crush No. 3 sieves, add 60% ethanol solution to reflux and extract twice, extract for the first time for 2 hours, and extract for the second time for 1.5 hours, filter and concentrate to obtain a thick paste I with a relative density of 1.20-1.30 ;

[0033] 2) Mix Gastrodia elata dregs in step 1) with Eucommia ulmoides and Eucommia leaves, add 10 times the amount of water to decoct three times, decoct for 2 hours for the first time, decoct for 1.5 hours for the second time, and decoct for 1 hour for the third time, and combine to obtain Decoction I: take Chuanxiong and wild chrysanthemum, add 10 times the amount of water to decoct twice, the first time 1.5h, the second time 1h, combine to obtain decoctio...

Embodiment 2

[0036] Example 2 Preparation of Qiangli Dingxuan Capsules of the present invention

[0037] Get the bulk drug prepared in Example 1, fill it in hard capsules, and obtain each 0.4 g Qiangli Dingxuan Capsules.

[0038] The beneficial effects of the present invention are illustrated below through test examples.

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Abstract

The invention discloses a novel powerful dizziness-relieving capsule and a preparation method thereof. The preparation method comprises the following steps: 1) taking 40-50% of gastrodia elata according to a formula ratio, crushing, adding an ethanol solution, extracting twice, filtering and concentrating an extracting solution to obtain thick paste I, 2) mixing the gastrodia elata dregs obtainedin the step 1) with eucommia ulmoides and eucommia ulmoides leaves, adding water, decocting for three times to obtain a decoction I, mixing Ligusticum wallichii and wild chrysanthemum flower, adding water, decocting twice to obtain a decoction II, combining the decoctions I and II, filtering, and concentrating the filtrate to obtain thick paste II, and 3) combining the thick paste I and the thickpaste II, drying, crushing and sieving to obtain extract powder, crushing and sieving 50-60% of gastrodia elata according to the formula ratio, performing superfine grinding to obtain gastrodia elatasuperfine powder, mixing the extract powder with the gastrodia elata superfine powder, and performing superfine grinding for 10-60 seconds to obtain the traditional Chinese medicine composition.

Description

technical field [0001] The invention specifically relates to a new Qiangli Dingxuan capsule and a preparation method thereof. Background technique [0002] The contents of Qiangli Dingxuan Capsules are composed of Gastrodia elata, Eucommia, wild chrysanthemum, Eucommia leaves, and Chuanxiong. The properties are brown granules and powders, with fragrant air and slightly bitter taste. It is mainly used for headache, dizziness, dizziness, tinnitus, insomnia and other diseases caused by hypertension, arteriosclerosis, hyperlipidemia and the above diseases. [0003] The contents of Qiangli Dingxuan Capsules belong to traditional Chinese medicine extract preparations, with complex components and water-soluble components, which are easily dissolved in the moisture in the air and cause hygroscopicity. Secondly, they contain a large amount of hydrophilic components such as polysaccharides and saponins. Adhesion, deliquescence, deterioration and other undesirable phenomena are prone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K9/48A61P9/12A61P9/10A61P3/06A61P1/08A61P25/00A61P29/00A61P27/02A61P27/16A61P25/20
CPCA61K9/48A61K36/236A61K36/287A61K36/46A61K36/8988A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P1/08A61P3/06A61P9/10A61P9/12A61P25/00A61P25/20A61P27/02A61P27/16A61P29/00A61K2300/00
Inventor 王媚史亚军邹俊波崔春利张小飞李婧琳郭东艳孙静
Owner SHAANXI UNIV OF CHINESE MEDICINE