Preparation and application of tissue repair-promoting hydrogels with both anti-tumor and antibacterial functions

Abstract

The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a tissue repair-promoting hydrogel with both anti-tumor and antibacterial functions. The preparation method of the tissue-repairing hydrogel of the present invention mainly comprises: firstly, using arginine to modify chitosan, and then physically compounding with polydopamine and nano-hydroxyapatite to form arginine-modified chitosan ‑polydopamine / nano hydroxyapatite solution, and finally the solution is cross-linked with a hydrophilic molecule (OHC‑PEG‑CHO) with both ends being aldehyde groups to form a hydrogel. The hydrogel for promoting tissue repair constructed by the invention has a three-dimensional network structure and can inhibit the growth of tumor cells and bacteria, but has no obvious inhibition on the growth of normal cells. The use of hydrogel for defect filling or skin wound repair after skin or soft tissue tumor resection can achieve efficient antibacterial, promote tissue repair, prevent scar tissue formation, and inhibit local tumor recurrence, and has a good clinical application prospect .

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a tissue repair-promoting hydrogel with both anti-tumor and antibacterial functions. Background technique [0002] Hydrogel (Hydrogel) is a hydrophilic polymer with water as the medium. It can swell significantly but cannot dissolve in water. It has a three-dimensional structure in space. The hydrophilic groups on the polymer chain form hydrogen bonds with water molecules. The connection makes it have a strong function of "locking" water, which can hold more than 90% of water, so the hydrogel has both solid and fluid properties, and can change from fluid to colloid under appropriate conditions. [0003] Chitosan is the deacetylated product of chitin, the only natural alkaline polysaccharide found so far, has no toxic side effects, has good biocompatibility and biodegradability, and is widely used in medicine, food, environmental p...

AI Technical Summary

Problems solved by technology

Because catechol has cell adhesion, it can change the tissue adhesion of chitosan, and can adsorb blood cells on the surface of the material to achieve better hemostatic effect; and improve the performance of chitosan and improve tissue affinity , and this material can be made into a new class of hemostatic sponge by freeze-drying, new dressings by spinning, or powder dressings by reverse flocculation, but this material cannot perform deep tissue repair, and there is no Inhibition of tumor recurrence

[0006] In summary, the existing chitosan hydrogels usually face problems such as poor cytocompatibility, difficulty in effective deep tissue repair, inability to effectively inhibit tumor recurrence, and limited practical applications.

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