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Preparation method of cortex lycii radicis extract for improving hygroscopicity

A technology of Digupi extract, which is applied in the field of extraction of traditional Chinese medicine components, can solve the problems of high production cost, complex production process, and inferior effect, and achieve the effect of low cost, simple operation, and improved hygroscopicity

Pending Publication Date: 2020-08-21
劲牌持正堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By adding anti-hygroscopic auxiliary materials in the extract, it can play a certain role in improving hygroscopicity, but the effect is not as good as the present invention, and the water absorption is improved by coating. Although the effect is obvious, the production process is obviously complicated, and the types of auxiliary materials used more, significantly more expensive to produce

Method used

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  • Preparation method of cortex lycii radicis extract for improving hygroscopicity
  • Preparation method of cortex lycii radicis extract for improving hygroscopicity
  • Preparation method of cortex lycii radicis extract for improving hygroscopicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 10kg of Digupi medicinal material, add 50L of pure water, extract at 50°C for 1 hour, filter to obtain the extract, extract three times under the same conditions, combine the three extracts and mix, concentrate at -0.01MPa, 60°C to 15L, add 0.2kgβ Cyclodextrin, stir at 50°C for 3 hours until β-cyclodextrin is completely dissolved and mixed evenly, then continue to concentrate to 5L at -0.02MPa, 60°C to form a paste, transfer to a spray dryer for drying, the drying conditions It is: under the conditions of vacuum degree of -0.045MPa~-0.08MPa, atomization pressure of 0.3~0.5MPa, feed temperature of 65±5°C, feed liquid concentration of 25% to 35%, and feed volume of 840 to 850mL / h, the air inlet temperature is 105±5°C, and after drying, the water content is about 3%. Take it out, pulverize it through a 40-mesh sieve, and obtain the Cortex Dictana extract powder.

[0028] Put the Digustifolia extract added with β-cyclodextrin obtained in this example and the Digusus e...

Embodiment 2

[0032] Take 10kg of Digupi medicinal material, add 100L of 30% ethanol, extract at 75°C for 2 hours, filter the extract, extract twice, combine the two extracts, concentrate to 25L at -0.05MPa, 70°C, add 0.5kg of β ring Dextrin, stirred at 70°C for 2 hours, until the β-cyclodextrin was completely dissolved and mixed evenly, continued to concentrate at -0.05MPa, 70°C to 3L, into a paste, transferred to a plate-type vacuum drying oven, at 70°C, -0.05MPa, dried to 4.5% water content, taken out, crushed through a 100-mesh sieve to obtain Digus bark extract powder.

[0033] Put the Digustifolia extract added with β-cyclodextrin obtained in this example and the Diguspis extract without adding β-cyclodextrin in a common humidity environment of 50% for 3 days, and the moisture absorption conditions are shown in Table 2 :

[0034] The moisture absorption situation of each group of table 2 embodiment 2 after placing 3 days under 50% humidity

[0035]

Embodiment 3

[0037] Take 10kg of Digupi medicinal material, add 200L of 60% ethanol, extract at 90°C for 3 hours, once, filter to obtain the extract, concentrate at -0.10MPa at 80°C to 40L, add 1.0kg of β-cyclodextrin, and stir at 90°C 1 hour, until the β-cyclodextrin is completely dissolved and mixed evenly, concentrated at -0.08MPa to 4L at 80°C, transferred to a belt vacuum dryer, the feeding speed is ≤30L / h; the crawler speed is ≤30cm / min; cloth The speed is 50~150rpm; the cloth angle is 5~30; the vacuum degree is -0.05MPa~-0.1MPa; the first stage≤120℃; the second stage≤120℃; the third stage≤120℃; , after drying, the water content is about 6%, taken out, crushed through a 200-mesh sieve, and obtained the Digus bark extract powder.

[0038] Put the Digustifolia extract added with β-cyclodextrin obtained in this example and the Digusus extract without adding β-cyclodextrin in a common humidity environment of 50% for 3 days, and the moisture absorption conditions are shown in Table 3 : ...

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Abstract

The invention relates to a preparation method of a cortex lycii radicis extract capable of improving hygroscopicity. The cortex lycii radicis extract is prepared by extracting and concentrating a cortex lycii radicis medicinal material, adding a certain amount of beta-cyclodextrin, uniformly mixing, carrying out spray drying or vacuum freeze drying or plate-type vacuum or belt-type vacuum drying,powdering and granulating. The cortex lycii radicis extract prepared by the method is remarkably reduced in hygroscopicity, so that the stability of the product is improved.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicine components, in particular to a method for improving the hygroscopicity of an extract of Cortex Dictica. Background technique [0002] Digupi, also known as wolfberry skin, is the root bark of wolfberry, a traditional Chinese medicine. It can cool blood and remove steam, clear lung and reduce fire, and has the effect of reducing fever and removing steam. It contains organic acids, alkaloids and flavonoids. Modern medical research shows that Digupi has the functions of lowering blood pressure, lowering blood sugar, antibacterial, and antipyretic. Chinese medicine formula granules. [0003] However, after the Digupi is extracted, the resulting extract has strong hygroscopicity, resulting in Digupi extract, Digupi formula granules, and traditional Chinese medicine and health food containing Digupi extract are easy to absorb moisture and deteriorate, shortening the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A23L33/105A61K125/00
CPCA61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A23L33/105
Inventor 周彬孙代华张雪元杨波曹菁褚飞洋
Owner 劲牌持正堂药业有限公司
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