Process for preparing an acid resistant cellulose capsule
A technology of cellulose and dissolving cellulose, which is applied in the direction of capsule delivery, medical preparations of non-active ingredients, pharmaceutical formulas, etc., to achieve the effect of improving film strength
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment
[0052] The present invention can be explained more specifically by the following Preparation Examples, Comparative Preparation Examples and Examples. However, it should be understood that these Preparation Examples, Comparative Preparation Examples and Examples are intended to illustrate and not to limit the scope of the present invention in any way.
[0053] (preparation example)
[0054] Preparation of acid-resistant cellulose capsule of the present invention
[0055] Dissolve 200g of cellulose in 0.8L of purified water heated to 90°C to obtain 1000g of dissolved cellulose aqueous solution. Subsequently, 28 g of amide pectin and 6 g of iota-carrageenan as gelling agents, 0.75 g of potassium carbonate and 0.75 g of calcium gluconate as auxiliary gelling agents, 0.2 g of ice as a pH neutralizer were added to the resulting mixture. Acetic acid, 0.5g sucrose fatty acid ester as emulsifier and 0.02g diacetylated monoglyceride, 0.3g colloidal silicon dioxide as viscosity stabili...
comparative preparation Embodiment 1
[0057] Preparation of acid-resistant cellulose capsule disclosed in WO 2011 / 36601
[0058] Dissolve 200g of cellulose in 0.8L of purified water heated to 80°C to obtain 1000g of dissolved cellulose aqueous solution. Subsequently, 28 g of gellan gum as a gelling agent, 0.5 g of sucrose fatty acid ester as an emulsifier were added to the resulting mixture and stirred. After cooling it slowly to 40°C, the dissolved cellulose mixture is obtained. The obtained cellulose mixture is then allowed to stand, equilibrated and its viscosity adjusted. After heating the cellulose mixture to 65°C, a forming pin was used to form a cellulose capsule. Finally, acid-resistant cellulose capsules can be manufactured after drying them.
[0059] The cellulose capsule prepared in Comparative Preparation Example 1 contained no auxiliary gelling agent, pH neutralizing agent, viscosity stabilizer and plasticizer in the cellulose capsule.
comparative preparation Embodiment 2
[0061] Preparation of acid-resistant cellulose capsules (without viscosity stabilizer and plasticizer)
[0062] Dissolve 200g of cellulose in 0.8L of purified water heated to 80°C to obtain 1000g of dissolved cellulose aqueous solution. Subsequently, 28 g of amide pectin and 6 g of iota-carrageenan as gelling agents, 0.75 g of potassium carbonate and 0.75 g of calcium gluconate as auxiliary gelling agents, 0.2 g of ice as a pH neutralizer were added to the resulting mixture. Acetic acid, 0.5 g of sucrose fatty acid ester as emulsifier and 0.02 g of diacetylated monoglyceride were stirred. After cooling it slowly to 40°C, the dissolved cellulose mixture is obtained. The obtained cellulose mixture is then allowed to stand, equilibrated and its viscosity adjusted. After heating the cellulose mixture to 65°C, a forming pin was used to form a cellulose capsule. Finally, acid-resistant cellulose capsules can be manufactured after drying them.
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More