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Metabolic composition for early detection of transplanted kidney acute rejection, screening method and application

A screening method and technology for early detection, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as lack of specificity and sensitivity

Active Publication Date: 2020-09-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nevertheless, the discovery of biomarkers for early renal impairment events typical of acute rejection after renal transplantation is still in the exploratory stage, and there is a lack of effective means with high specificity and sensitivity

Method used

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  • Metabolic composition for early detection of transplanted kidney acute rejection, screening method and application
  • Metabolic composition for early detection of transplanted kidney acute rejection, screening method and application
  • Metabolic composition for early detection of transplanted kidney acute rejection, screening method and application

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Embodiment 1

[0038] Patients with clinical manifestations such as oliguria, fever, and weight gain after kidney transplantation, whose serum creatinine increased by more than 20% compared with the baseline value within 1 year after transplantation, and patients with acute rejection confirmed by biopsy of the transplanted kidney were taken as the acute rejection group, that is, the AR group , patients with stable renal function recovery after kidney transplantation were used as the stable transplantation group, and healthy people were used as the healthy control group. Urine samples were obtained from the above three groups.

[0039] If the acute rejection group received 2 kidney transplants, multi-organ combined transplantation, or death-row prisoner kidney surgery, and no biopsy was confirmed, or acute rejection was accompanied by polyoma virus infection and acute tubular injury, they were excluded . If the creatinine in the stable transplantation group fails to stabilize within 20% of th...

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Abstract

The invention discloses a metabolic composition for early detection of transplanted kidney acute rejection. The metabolic composition is composed of one or more of 10 metabolite combinations of aminopterin, cane sugar, estrone, galactoinositol, cortisone, quinolone sugar, lactose, lyxose, palmitic acid and catechol. The invention further discloses a screening method of the metabolic composition. In the screened metabolite composition, the levels of aminopterin, cane sugar, estrone, galactoinositol, cortisone, quinolone sugar, lactose and lysose are increased, and the levels of palmitic acid and catechol are reduced, so that the metabolite composition has guiding significance for diagnosis of acute rejection; in the metabolite composition, the independent indication rate of the metabolite is 0.609-0.762, and the binding indication rate reaches 0.792; and in the metabolite composition, the core components are sucrose, galactoinositol, lactose, lyxose and quinolone sugar which jointly participate in a galactose metabolic pathway.

Description

technical field [0001] The invention relates to a metabolic composition, screening method and application for early detection of acute rejection of transplanted kidneys. Background technique [0002] Uremia is a major disease affecting human health, and kidney transplantation is the most effective solution. Since the first successful kidney transplantation in 1954, nearly one million uremic patients worldwide have received kidney transplantation in more than 60 years, greatly improving the quality of life of patients. Acute rejection of kidney transplantation (Acute Rejection, AR) is a common complication after kidney transplantation, which can affect the long-term survival rate of kidney transplantation and patients. According to the pathogenesis, it can be divided into two types: Cellular Mediated Rejection (CMR) and Antibody Mediated Rejection (AMR). At present, it is believed that the essence of acute rejection is cellular immune response. T cells are activated under t...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/54
CPCG01N30/02G01N30/06G01N30/54G01N30/7266G01N2030/027G01N2030/062
Inventor 黄洪锋王仁定陈江华邓皓沈佳
Owner ZHEJIANG UNIV
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