Metal organic framework composite nanomaterial with targeting property and pH responsiveness as well as preparation method and application of metal organic frame composite nanomaterial
A metal-organic framework and composite nanomaterial technology, applied in the field of material science, can solve the problems of increasing T cell anti-tumor, lack of targeting ability, drug leakage, etc., achieving high drug loading rate, enhancing the content and effect of anti-tumor substances Good results
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Embodiment 1
[0063] Example 1: CD63-apt@CaCO3@ZIF-8@BSA
[0064] (1) Preparation of ZIF-8-encapsulated bovine serum albumin (ZIF-8@BSA):
[0065] First, 4 mg of bovine serum albumin (BSA) was prepared into an aqueous solution with 8 mL of distilled water, 8 mg of polyvinylpyrrolidone (PVP) was added to the aqueous solution of bovine serum albumin, and stirred gently for 30 seconds; then 4 mg of L-cysteine (L-cys) was added to the above reaction system, and stirred gently for 30 seconds after ultrasonic dispersion; finally, 8 mL of an aqueous solution containing 105 mg of 2-methylimidazole (2-mIM) and an aqueous solution of 73 mg of zinc acetate dihydrate were added to the system 8mL. After standing at room temperature for 6 hours, the core particles were collected by washing with distilled water several times and centrifuged.
[0066] (2) Calcium carbonate-wrapped metal-organic framework material CaCO 3 Preparation of @ZIF-8@BSA:
[0067] First, 7.5mL of cyclohexane, 1.77mL of Triton X...
Embodiment 2
[0070] Example 2: ROX-CD63-apt@CaCO3@ZIF-8@BSA
[0071] (1) Preparation of ZIF-8-encapsulated bovine serum albumin (ZIF-8@BSA):
[0072] First, 4 mg of bovine serum albumin (BSA) was prepared into an aqueous solution with 8 mL of distilled water, 8 mg of polyvinylpyrrolidone (PVP) was added to the aqueous solution of bovine serum albumin, and stirred gently for 30 seconds; then 4 mg of L-cysteine (L-cys) was added to the above reaction system, and stirred gently for 30 seconds after ultrasonic dispersion; finally, 8 mL of an aqueous solution containing 105 mg of 2-methylimidazole (2-mIM) and an aqueous solution of 73 mg of zinc acetate dihydrate were added to the system 8mL. After standing at room temperature for 6 hours, the core particles were collected by washing with distilled water several times and centrifuged.
[0073] (2) Calcium carbonate-wrapped metal-organic framework material CaCO 3 Preparation of @ZIF-8@BSA:
[0074] First, 7.5mL of cyclohexane, 1.77mL of Trit...
Embodiment 3
[0077] Example 3: CD63-apt@CaCO3@ZIF-8@BSA-TRITC
[0078] (1) Preparation of ZIF-8-encapsulated fluorescent bovine serum albumin (ZIF-8@BSA-TRITC):
[0079]First, 4 mg of bovine serum albumin (BSA) was prepared into an aqueous solution with 8 mL of distilled water, 8 mg of polyvinylpyrrolidone (PVP) was added to the aqueous solution of bovine serum albumin, and stirred gently for 30 seconds; then 4 mg of L-cysteine (L-cys) was added to the above reaction system, and stirred gently for 30 seconds after ultrasonic dispersion; finally, 8 mL of an aqueous solution containing 105 mg of 2-methylimidazole (2-mIM) and an aqueous solution of 73 mg of zinc acetate dihydrate were added to the system 8mL. After standing at room temperature in the dark for 6 hours, the core particles were collected by washing with distilled water several times and centrifuged.
[0080] (2) Calcium carbonate-wrapped metal-organic framework material CaCO 3 Preparation of @ZIF-8@BSA-TRITC:
[0081] First,...
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