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A kind of preparation method of antibacterial hydrogel dressing containing imidazolium salt and hyaluronic acid

A technology of hyaluronic acid and imidazolium salt, applied in medical science, bandages, etc., can solve problems such as poor effect, and achieve the effects of promoting cell migration, wound antibacterial wound healing, and mild reaction conditions

Active Publication Date: 2021-10-22
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the above-mentioned hyaluronic acid antibacterial hydrogel dressing is mainly loaded with antibacterial agents by physical wrapping and has poor effect, the present invention provides a preparation method of an antibacterial hydrogel dressing containing imidazolium salt and hyaluronic acid

Method used

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  • A kind of preparation method of antibacterial hydrogel dressing containing imidazolium salt and hyaluronic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Weigh 0.015mmol hyaluronic acid (molecular weight (Mw)=60000) and dissolve it in 250ml phosphate buffer (PBS), then add 0.01mol dehydrating agent 4-(4,6-dimethoxytriazin-2-yl) -4-Methylmorpholine hydrochloride and 0.01mol furfurylamine were reacted in a water bath at 36°C for 56 hours. After the reaction, the solution was transferred to a dialysis bag (molecular weight cut-off (MWCO) = 8000Da, American Spectrum Medicine, EXP2022 / 5, the same below), dialyzed for 48 hours, and freeze-dried at -50°C to obtain hyaluronic acid-grafted bran amine.

[0024] The above-mentioned hyaluronic acid-grafted furfurylamine, polybutylimidazole furoate with a molecular weight of 1200, and N-maleimide four-armed polyethylene glycol with a molecular weight of about 10,000 are in a molar ratio of 1:0.5: 1 ratio, click reaction was carried out at 37°C and a polymer solution with a mass fraction of 10% was formulated with phosphate buffered solution (PBS), in which the molecular weight of fo...

Embodiment 2

[0026] Weigh 0.014mmol hyaluronic acid (Mw=70000) and dissolve it in 250ml phosphate buffer solution (PBS), then add 0.01mol dehydrating agent 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide salt Acid compound N-hydroxysulfosuccinimide and 0.01mol furfurylamine, reacted in a water bath at 37°C for 72 hours. After the reaction, the solution was transferred to a dialysis bag (MWCO = 8000Da), dialyzed for 48 hours, and freeze-dried at -50°C to obtain hyaluronic acid-grafted furfurylamine.

[0027] The above hyaluronic acid-grafted furfurylamine, polybutylimidazole furoate with a molecular weight of 1100, and N-maleimide four-armed polyethylene glycol with a molecular weight of about 20,000 are in a molar ratio of 1:1: 1 ratio, click reaction was carried out at 35°C and a polymer solution with a mass fraction of 10% was formulated with phosphate buffered solution (PBS), in which the molecular weight of four-armed polyethylene glycol was about 15,000. Subsequently, put it into an ov...

Embodiment 3

[0029] Weigh 0.011mmol hyaluronic acid (Mw=90000) and dissolve it in 250ml phosphate buffer solution (PBS), then add 0.01mol dehydrating agent 4-(4,6-dimethoxytriazin-2-yl)-4- Methylmorpholine hydrochloride and 0.01mol furfurylamine were reacted in a water bath at 45°C for 68 hours. After the reaction, the solution was transferred to a dialysis bag (MWCO = 8000 Da), dialyzed for 72 hours, and freeze-dried at -50°C to obtain hyaluronic acid-grafted furfurylamine.

[0030] The above-mentioned hyaluronic acid-grafted furfurylamine, polyhexylimidazole furoate with a molecular weight of 2000, and N-maleimide four-armed polyethylene glycol with a molecular weight of about 35000 are in a molar ratio of 1:1:2 Click reaction was carried out at 32°C and a polymer solution with a mass fraction of 10% was prepared with phosphate buffered solution (PBS), in which the molecular weight of four-armed polyethylene glycol was about 30,000. Subsequently, put it into an oven at 40° C. and let it...

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Abstract

The invention discloses a preparation method of an antibacterial hydrogel dressing containing imidazolium salt and hyaluronic acid, comprising the steps of preparing modified hyaluronic acid containing click-reactive functional groups and preparing imidazolium salt and hyaluronic acid by click reaction The step of the hydrogel dressing, the hydrogel dressing prepared by the click reaction of the present invention contains imidazolium salt and hyaluronic acid, so that the antibacterial effect is excellent.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of an antibacterial hydrogel dressing containing imidazolium salt and hyaluronic acid. Background technique [0002] As a new type of medical dressing, antibacterial hydrogel has good softness and elasticity, can relieve pain, has good tissue compatibility, and will not bond wounds, thereby reducing secondary damage caused by changing dressings. In addition, it can also absorb a large amount of wound penetration, avoid fluid accumulation between the wound and auxiliary materials, have a certain function of resisting bacterial invasion, and reduce wound surface infection. Among them, the method of Diels-Alder "click chemistry" and mercapto-alkyne "click chemistry" is used to prepare hyaluronic acid hydrogel, which has the advantages of mild gelation conditions and fast gelation rate. The prepared hyaluronic acid hydrogel is still Important anti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00
CPCA61L26/0023A61L26/0066A61L26/008A61L2300/216A61L2300/404C08G81/00C08L5/08
Inventor 周超生程钜刘博
Owner CHANGZHOU UNIV
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