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Application of traditional Chinese medicine composition to preparation of medicine for treating or preventing coronavirus infection
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A coronavirus, composition technology, applied in the field of disease treatment drugs
Active Publication Date: 2020-11-03
JIANGSU KANION PHARMA CO LTD
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At present, there are no effective vaccines and drugs to prevent and control. Traditional Chinese medicine has played an important role in the prevention and treatment of "epidemic" and other severe infectious diseases since ancient times. At the same time, it has the overall comprehensive regulatory effect of broad-spectrum antibacterial, antiviral, and immune regulation
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Embodiment 1
[0028] Embodiment 1: the preparation of Chinese medicine compound capsule
[0029] The composition of the compound recipe is: 400g honeysuckle, 400g forsythia, 240g mint, 160g nepeta, 200g light tempeh, 240g burdock (fried), 240g bellflower, 160g light bamboo leaves, 200g licorice.
[0030] Take honeysuckle and add 80% ethanol to reflux extraction twice, each time for 1 hour, filter, combine the filtrate, recover ethanol, concentrate to a thick paste with a relative density of 1.28-1.30 (80°C);
[0031] Add water to boil light soya bean, soak twice at 80°C for 2 hours each time, filter, combine the filtrate, and set aside;
[0032] Extract volatile oil from peppermint, nepeta, and forsythia, and collect the distilled aqueous solution in another device;
[0033] Add water to decoct medicinal dregs, burdock seeds, light bamboo leaves, licorice, and Platycodon grandiflorum twice, each time for 2 hours, filter, and combine the filtrates; combine the above medicinal liquids (inclu...
[0036] Drug to be tested: the sample prepared in Example 1.
[0037] Cells: VeroE6 cells, preserved by the Virus Laboratory of the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Health.
[0038] Virus: SARS-CoV-2, titer TCID 50 =10 -6 / 100μL, stored at -80°C by BSL-3 Laboratory of Guangzhou Customs Technical Center (Highly PathogenicPathogenic Microorganism Research Laboratory of State Key Laboratory of Respiratory Diseases); use a virustiter of 100TCID 50 .
[0039] 2. Experimental method
[0040] In a sterile 96-well culture plate, add 100 μL to each well with a concentration of 2×10 5 cells / mL VeroE6 cells, 37℃5%CO 2 Cultivate for 24 hours; add 100 TCID to the culture plate experimental group and virus control group 50 Virus solution 100 μL / well, 37°C 5% CO 2 Adsorb in the incubator for 2 hours; after 2 hours, discard the cell culture medium in the 9...
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Abstract
The invention discloses an application of a traditional Chinese medicine composition to treating or preventing coronavirus infection. The traditional Chinese medicine composition is characterized by comprising 2-10 parts of honeysuckle, 2-10 parts of fructus forsythiae, 2-6 parts of mint, 2-4 parts of herba schizonepetae, 2-5 parts of fermented soybeans, 2-6 parts of fried fructus arctii, 2-6 parts of platycodon grandiflorum, 2-4 parts of lophatherum gracile and 2-5 parts of licorice roots. The inhibition effect of the traditional Chinese medicine composition on the novel coronavirus SARS-CoV-2 under different concentrations is investigated on VeroE6 cells, and experimental results show that the traditional Chinese medicine composition has a good protection effect on VeroE6 cells infectedby 2019-nCoV viruses under the concentrations of 2000[mu] g / ml, 1000[mu] g / ml and 500[mu] g / ml; and therefore, the traditional Chinese medicine composition disclosed by the invention has a good effectof treating or preventing coronavirus related diseases.
Description
technical field [0001] The invention relates to the field of medicines for treating diseases, and more specifically, relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating or preventing coronavirus infection. Background technique [0002] A type of viral pneumonia of unknown cause. Its clinical manifestations are fever, cough, shortness of breath, and dyspnea. In severe cases, it can lead to severe acute lung injury, acute respiratory distress syndrome, multiple organ failure, and even death. The World Health Organization (WHO) named the virus that caused the disease "severe acute respiratory syndrome coronavirus 2 (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)" and named the viral pneumonia COVID-19. [0003] How to effectively treat it is the key problem that needs to be overcome urgently. At present, there are no effective vaccines and drugs to prevent and control. Traditional Chinese medicine ...
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