The present invention relates to a soft-shelled turtle feed helpful for enhancing disease resistance. Raw materials of the soft-shelled turtle feed consist of main materials and auxiliary materials in parts by weight: wherein the main materials comprise 15 parts of gynura bicolor powder, 6 parts of Lythrum salicaria powder, 10 parts of bioactive proteins, 4 parts of hydrolyzed animal proteins, 20 parts of white fish meal, 6 parts of red fish meal, 8 parts of alpha-starch, 7 parts of Trident fish meal, 9 parts of Arctic ice fish meal, 5 parts of fish meal imported from Russia, 2 parts of yeast, 3 parts of calcium dihydrogen phosphate, 1 part of turtle multi-vitamin and 1 part of turtle multi-mineral; the auxiliary materials comprise 0.5 part of viable bacterium inhibitor, 0.5 part of ginseng root powder, 0.5 part of fructus lycii, 0.5 part of licorice root, 0.8 part of largehead atractylodes rhizome and 0.2 part of antioxidant. The use of the soft-shelled turtle feed shows a rapid growth of the soft-shelled turtle, a high feed conversion rate and a good breeding efficiency, and can significantly enhance the immune function and the anti-stress ability of the soft-shelled turtle.