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Low-molecular-weight sulfated galactosan as well as preparation method and application thereof

A galactan, low molecular weight technology, applied in the field of low molecular weight sulfate galactan and its preparation, can solve problems such as drug listing

Active Publication Date: 2020-11-03
MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on PTP1B inhibitors has attracted much attention, but there is no drug targeting this target on the market, which has a good prospect for clinical application

Method used

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  • Low-molecular-weight sulfated galactosan as well as preparation method and application thereof
  • Low-molecular-weight sulfated galactosan as well as preparation method and application thereof
  • Low-molecular-weight sulfated galactosan as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment provides a kind of low molecular weight galactan sulfate, its chemical structure is made up of the structural unit represented by general formula (I) and the structural unit represented by general formula (II),

[0043]

[0044] Among them, R 1 =SO 3 - , R 2 =H,R 3 =H; 15≤n≤100.

[0045] The preparation method of above-mentioned low molecular weight galactan sulfate, comprises the steps:

[0046] (1) Rinse off the salinity on the surface of the gocha with tap water, dry, chop, and extract with hot water and 5-10% alkaline aqueous solution (NaOH or KOH) for 1 hour; filter; and then extract the residue according to the above process 1-2 times; combine multiple extracts, concentrate to 2% of the original volume of the extract, precipitate with 3 times the volume of ethanol, centrifuge, dry, and pulverize to obtain crude galactan sulfate;

[0047] (2) Dissolve the crude polysaccharide in a dilute acid solution of 0.05mol / L, the concentration of the ...

Embodiment 2

[0050] This embodiment provides a kind of low molecular weight galactan sulfate, its chemical structure is made up of the structural unit represented by general formula (I) and the structural unit represented by general formula (II),

[0051]

[0052] Among them, R 1 =H,R 2 =SO 3 - , R 3 = SO 3 - ; 15≤n≤100.

[0053] The preparation method of above-mentioned low molecular weight galactan sulfate, comprises the steps:

[0054] (1) Rinse off the surface salinity of Argonaut algae with tap water, dry, chop, and extract with hot water for 1 hour; filter; extract the residue 1-2 times according to the above process; combine multiple extracts, concentrate to 2% of the original volume of the extract, precipitated with 3 times the volume of ethanol, centrifuged, dried, and pulverized to obtain crude galactan sulfate;

[0055] (2) Dissolve the crude polysaccharide in a dilute acid solution of 0.05mol / L, the concentration of the crude polysaccharide in the solution is 5%, hea...

Embodiment 3

[0058] This embodiment provides a kind of low molecular weight galactan sulfate, its chemical structure is made up of the structural unit represented by general formula (I) and the structural unit represented by general formula (II),

[0059]

[0060] Among them, R 1 =H,R 2 = SO 3 - , R 3 = SO 3 - ; 15≤n≤100.

[0061] The preparation method of above-mentioned low molecular weight galactan sulfate, comprises the steps:

[0062] (1) Rinse off the surface salinity of the algae with tap water, dry, chop, and extract with hot water for 1 hour; filter; extract the residue 1-2 times according to the above process; combine multiple extracts, and concentrate to 2% of the original volume of the extract, precipitated with 3 times the volume of ethanol, centrifuged, dried, and pulverized to obtain crude galactan sulfate;

[0063] (2) Dissolve the crude polysaccharide with 0.05mol / L dilute acid solution, the concentration of crude polysaccharide in the solution is 5%, heat the r...

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Abstract

The invention discloses low-molecular-weight sulfated galactosan as well as a preparation method and application thereof. According to the method, different types of rhodophyta are used as raw materials, and the low-molecular-weight galactosan sulfate with different molecular weight sections is prepared through one-step extraction, degradation, separation and purification. The low-molecular-weightgalactosan sulfate provided by the invention can selectively inhibit PTP1B, improve glucose consumption of cells under insulin resistance conditions, improve insulin sensitivity, adjust energy consumption and maintain glucose homeostasis. The galactosan sulfate is expected to be developed into a medicine for preventing and / or treating type II diabetes and obesity, or developed into a food with the functions of reducing blood sugar, blood fat and weight, and has a good market application prospect.

Description

technical field [0001] The invention relates to the technical field of sulfated galactan oligosaccharides, in particular to a low-molecular-weight sulfated galactan and its preparation method and application. Background technique [0002] Diabetes Mellitus (DM) is a chronic metabolic disease. Among the three main types of diabetes, type 2 diabetes accounts for about 90%. Type Ⅱ diabetes is a chronic progressive metabolic disease, its onset is related to age, lifestyle, genetic factors, obesity and viral infection, and is regulated by a variety of key genes, such as PPARG, IRS-1, IGF -1 and CDKN2B etc. The pathogenesis of type Ⅱ diabetes includes insulin resistance, glucotoxicity, lipotoxicity, oxidative stress, genetic defects, and inflammatory response, etc., which are mainly related to insulin resistance. Insulin resistance is the result of a combination of many primary, genetic and secondary, environmental factors, including defects in insulin secretion and defects in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/737A61P3/10A61P3/04A61P3/06A23L33/00A23L33/125A23L33/105
CPCC08B37/0003C08B37/0036C08B37/0042A61K31/737A61P3/10A61P3/04A61P3/06A23L33/00A23L33/125A23L33/105A23V2002/00A23V2250/21A23V2200/328A23V2200/332A23V2200/3262
Inventor 胡婷管华诗辛萌路晓李建杰于广利赵峡李春霞郑梦梦杨萌琳
Owner MARINE BIOMEDICAL RES INST OF QINGDAO CO LTD
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