34 results about "Antifungal antibiotic" patented technology

Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.

Disclosed is Bacterium of the species Lactobacillus rhamnosus CHCC15860 as deposited with the German Collection of Microorganisms and Cell Cultures (DSMZ) under accession No. DSM32092. Also disclosed are compositions comprising the bacterium, methods for producing fermented milk products using the bacterium and the products thus obtained.

The present invention discloses a kind of Ustilago esculenta strain UEZC1 capable of producing antifungal antibiotic and its use. The Ustilago esculenta strain UEZC1 features that the teleutospore is germinated on potato glucose liquid culture medium to form basidium promycelium with 1-4 basidiospore promycelia, and the basidiospore after falling off further grow to form fusiform short hypha for inserting basidiospore. The present invention can produce antifungal antibiotic, and may be used in developing and producing medical and agricultural antifungal antibiotic.

The invention relates to a method for rapid selection of plant disease-resistant fungi marine microorganism which comprises, (1) conducting parallel bacteriostasis experiment with Candida rugosa strain and plant disease resistant fungous antibiotics, choosing Candida rugosa strain capable of serving as indicating bacterium, (2) using the Candida rugosa strain obtained in step (1) as indicating bacterium to screen ocean microorganism with inhibitory actions.

The invention discloses a fermentation medium for producing polyene macrolide antifungal antibiotics by fermentation of Streptomyces multichromogenes and a preparation method thereof, belonging to the technical field of fermentation engineering and biological pesticides. The fermentation medium includes sugar carbon source, organic nitrogen source, inorganic nitrogen source, inorganic salt, yeast extract and amylase; the preparation method comprises the following steps: (1) after mixing the carbohydrate carbon source and amylase, add water and heat to form carbohydrate carbon source material enzyme solution; (2) mix organic nitrogen source, inorganic nitrogen source, inorganic salt and yeast extract and add water to heat to form a nitrogen source material mixture; (3) mix carbohydrate carbon source material enzymatic hydrolysis solution and nitrogen source material mixture , then make up water, and finally adjust the pH value of the solution to 3 to 10 with hydrochloric acid and sodium hydroxide; the present invention aims to provide a fermentation medium and its Preparation method: used for fermenting Streptomyces chromogenes to produce polyene macrolide antifungal antibiotics.

The invention discloses a gene (LrGSTU3) of lilium regale with antifungal activity and an application thereof. The nucleotide sequence of the gene (LrGSTU3) is shown as SEQIDNO:1 to encode tau glutathione S-transferase. Functional genomics related technical research shows that the gene (LrGSTU3) of lilium regale has the function of improving the antifungal ability of the plant. The gene (LrGSTU3) of lilium regale disclosed by the invention is constructed to a plant expression vector and transformed to tobacco to be over-expressed, so that the transgenetic tobacco strain is strong in vitro antifungal activity, and the transgenetic tobacco sheet which over-expresses (LrGSTU3) has a remarkable inhibiting effect on growth of fusarium oxysporum and botrytis cinerea.

Antifungal compounds having a benzofuran structure. Antifungals exhibit much less toxicity to human cells than amiodarone. These compounds are useful alone or in combination with other compounds having antifungal activity. Compounds of this invention exhibit synergistic antifungal activity in combination with antifungal amiodarone compounds. The invention provides pharmaceutical compositions useful for treating fungal infections, methods for treating fungal infections and compounds useful in such compositions for treating fungal infections. Compounds of this invention are further useful as antifungal agents for the prevention and or treatment of fungal infections in plants. The invention includes agriculturally useful compositions comprising one or more compounds of this invention which exhibit fungistatic or fungicidal function against one or more plant pathogen is a fungus.

The invention provides semisynthetic derivatives of Nystatin A1, water soluble salts and complexes, pharmaceutical compositions and plant protection products comprising the derivatives and their use, as antifungal antibiotics (Formula 1a).

The invention discloses a novel compound II with antifungal activity. The chemical components of Selaginella pulvinata Maxim are subjected to systematic intensive study, and the spectrum and mass spectrometric data analysis proves that the novel compound II is separated from the Selaginella pulvinata Maxim. The in-vitro antifungal activity research proves that the compound II disclosed by the invention has the effects of obviously inhibiting multiple pathogenic fungi such as Candida albicans, aspergillus fumigatus, trichophyton rubrum and alpha fungus, is low in toxicity and safe in clinical administration, and is expected to be developed into a novel antifungal medicament.