34 results about "Antifungal antibiotic" patented technology

The present invention is directed to the design, synthesis and use of various β-peptides exhibiting antifungal activity. The β-peptides are relatively short in length, adopt globally amphiphilic conformations, and cause little lysis of human red blood cells at concentrations that kill Candida albicans, a common human fungal pathogen.

An oral rinse formulation for the treatment or prophylaxis of mucositis or stomatitis comprises one or more of the following components in combination with pharmaceutically acceptable excipients or additives: a) at least one corticosteroid; b) at least one anti-histamine; c) at least one topical anaesthetic; d) at least one antibiotic agent; and, e) at least one anti-fungal antibiotic agent. A method of treating or preventing mucositis or stomatitis using such formulation is provided.

The present invention discloses a kind of Ustilago esculenta strain UEZC1 capable of producing antifungal antibiotic and its use. The Ustilago esculenta strain UEZC1 features that the teleutospore is germinated on potato glucose liquid culture medium to form basidium promycelium with 1-4 basidiospore promycelia, and the basidiospore after falling off further grow to form fusiform short hypha for inserting basidiospore. The present invention can produce antifungal antibiotic, and may be used in developing and producing medical and agricultural antifungal antibiotic.

The invention discloses a disease controlling microbial fertilizer special for tuberous crops and a preparation method thereof, in particular to a microbial fertilizer special for controlling sweet potato black rot and a preparation method thereof. The microbial fertilizer is prepared by mixing of the following raw materials: antimycoin streptomyces powder, wet streptomyces powder, paenibacillus pabuli powder, paenibacillus jamilae powder, and potassium fulvate raw powder. The strains involved in the invention can utilize the antibiosis, competition, hyperparasitism and bacteriolysis effects between or within microbial species, or utilize secondary metabolites to induce disease resistance of sweet potatoes, and can produce a variety of antibiotics like endomycin compound, non-polyene antifungal antibiotics, dihydrostreptomycin, humidin and cobalamin to inhibit sweet potato black rot pathogenic bacteria and strengthen the disease prevention effect. The microbial fertilizer provided by the invention is safe to human and livestock, and is environment-friendly. Application of the microbial fertilizer provided by the invention to control of sweet potato black rot is not easy to produce drug resistance. The microbial fertilizer has the advantages of simple preparation method, low cost and easy use.

The invention discloses a composite microbial fertilizer for control of botrytis cinerea and a preparation method thereof. The composite microbial fertilizer is prepared by mixing of the following raw materials: a Str. Viridifaciens fermentation broth, a S. champavatii fermentation broth, an India bacillus fermentation broth, a B. mojavensis fermentation broth, and a Trichoderma ovalisporium fermentation broth. The strains involved in the invention can comprehensively utilize the antibiosis, competition, hyperparasitism and bacteriolysis effects between or within microbial species, or utilize secondary metabolites to induce the disease resistance of tomatoes, and can generate a variety of antibiotics like tetracycline, 7-aureomycin, champamycin A and B (antifungal antibiotics of heptaene) and champavatin to inhibit botrytis cinerea pathogenic bacteria and strengthen its disease prevention effect. The composite microbial fertilizer provided by the invention is safe to human and livestock, is environment-friendly, and does not produce drug resistance when applied to control of botrytis cinerea. The composite microbial fertilizer has the advantages of simple preparation method, low cost, and easy use.

The invention discloses an aspergillus unguis bromo-depsidone compound and a preparation method and application thereof. The chemical structure formula of the aspergillus unguis bromo-depsidone compound is shown as the formula (I) in the accompanying drawing. The compound is obtained by inoculating aspergillus unguis DLEP2008001 into a fungus culture medium; performing still standing fermentation; extracting fermentation liquid by ethyl acetate; extracting mycelia by an organic solvent; after the merging, performing gradient silicagel column chromatography by an organic solvent; through the silicagel thin layer chromatography detection, continuously performing silicagel column and gel column chromatography on the elution fractions containing target subjects; performing normal phase preparation liquid chromatographic separation purification. The compound can be used for inhibiting fungus white candida, gram-negative bacterium pseudomonas aeruginosa and gram-positive bacterium methoxyl-resistant penicillin staphylococcus aureus and killing artemia larvae, and the potential purposes of antifungal antibiotics, antibacterial antibiotics or pesticides are realized.

The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having inhibitory activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi.

An orchid extract comprises at least one antifungal component, and the extract is extracted from an orchid part, and the antifungal component has antifungal activity. An orchid extract addition product is prepared by adding that orchid extract into a raw material to prepare an antifungal composition.

Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.

The invention discloses a new compound I with the antifungal activity. The new compound I is obtained by systematic in-depth study on the chemical components of selaginella pulvinata maxim and separation from the selaginella pulvinata maxim through analysis on wave spectrum and mass spectrum data. Shown by in-vitro antifungal activity, the new compound I provided by the invention has obvious inhibiting effect on candida albicans, aspergillus fumigates, trichophyton rubrum and alpha fungus and the like, is low in toxicity and can be developed into a new antifungal medicine.

An object of the present invention is to provide a novel strain that is capable of effectively inhibiting the growth of microorganisms such as fungi and Staphylococcus aureus, is safe, and does not influence the flavor and taste of foods. The present invention relates to a strain of Lactobacillus sanfranciscensis WB1006 (FERM ABP-11246), and also relates to a food produced with the use of the strain.

A novel ascomycetous Xylogone ganodermophthora strain has antifungal activity. A composition includes the strain as an active ingredient for preventing plant diseases. The strain suppresses the growth of pathogenic fungi, including Phytophthora capsici, in plants. Therefore, the composition containing the strain, or a culture or extract thereof, as an active ingredient for preventing plant diseases has excellent antifungal activity and can thus be used as an environmentally friendly and pollution-free pesticide.

The present invention refers to the application of extracts of Cymbopogon nardus in the preparation of pharmaceutical compositions with antifungal activity and to the process of obtaining the referred to extracts as well as their use as active component of the referred to compositions employed in the treatment of mycoses.

The invention is also with respect to the compositions containing the vegetal extract obtained from the aerial parts of a plant of the Graminae family with antifungal activity. Preferably the vegetal extract is obtained from the leaves of the plant. Even more preferably the plant used is Cymbopogon nardus (L.) Rendle.