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Composition for preventing and treating candidiasis and medicine and feed additive containing the composition

A technology of Candida albicans and composition, which is applied in the field of medicine and can solve problems such as food safety

Active Publication Date: 2022-05-27
BIOFORTE BIOTECHNOLOGY (SHENZHEN) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pigeon breeding industry uses acidifiers and antibiotics to prevent and control Candida albicans infection, which will lead to food safety problems

Method used

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  • Composition for preventing and treating candidiasis and medicine and feed additive containing the composition
  • Composition for preventing and treating candidiasis and medicine and feed additive containing the composition
  • Composition for preventing and treating candidiasis and medicine and feed additive containing the composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Citrus oil, thyme oil, garlic oil, and cinnamaldehyde are mixed into a plant essential oil composition in a mass ratio of 1:1:1:2, as the composition for preventing and treating candidiasis albicans according to the present invention, and then adding a composition containing 0.5% (v / v) Sterile distilled water of Tween-80, which is formulated into a drug with a concentration of 0.5% (v / v), and shaken evenly using a vortex shaker. Sterile distilled water containing 0.5% (v / v) Tween-80 was used as a control. The test strains were Candida albicans A, B, C strains. 2 × 10 obtained by counting viable bacteria 7 50ul of CFU / ml bacterial solution was added to a sterile petri dish. Then, the high-pressure post-YPD medium at about 60°C was poured into a sterile petri dish and shaken to mix. Each plate is equally divided into 4 areas. After the medium is solidified, use sterile tweezers to take a sterile Oxford cup of the same size and place it on the surface of the agar plate...

Embodiment 2

[0032] Citrus oil, thyme oil, garlic oil, and cinnamaldehyde are mixed into a plant essential oil composition in a mass ratio of 2:3:2:4: as the composition for preventing and treating candidiasis albicans of the present invention, and then adding a composition containing 0.5% (v / v) Sterile distilled water of Tween-80, which is prepared into a drug with a concentration of 0.5% (v / v), and shaken evenly using a vortex shaker. Sterile distilled water containing 0.5% (v / v) Tween-80 was used as a control. The test strains were Candida albicans A, B, C strains. 2 × 10 obtained by counting viable bacteria 7 50ul of CFU / ml bacterial solution was added to a sterile petri dish. Then, the high-pressure post-YPD medium at about 60°C was poured into a sterile petri dish and shaken to mix. Each plate is equally divided into 4 areas. After the medium is solidified, use sterile tweezers to take a sterile Oxford cup of the same size and place it on the surface of the agar plate in each are...

Embodiment 3

[0034] Citrus oil, thyme oil, garlic oil, and cinnamaldehyde are mixed in a mass ratio of 1:1:1:2 to form a plant essential oil composition, and Ligustrum lucidum, golden cherry seed, raisin seed, myristica alba, and Bo Luohui are extracted. According to the mass ratio of 1:2:2:2.5:1, the plant extracts are mixed into a plant extract composition, and the plant essential oil composition and the plant extract composition are prepared in a mass percentage of 1:1 to form the composition for preventing and treating candidiasis albicans of the present invention. Then add sterile distilled water containing 0.5% (v / v) Tween-80, configure the composition for preventing and treating candidiasis albicans of the present invention into a drug with a concentration of 0.5% (v / v), and use a vortex shaker to oscillate evenly . The experimental method is the same as that of Example 1 and Example 2. Table 1 shows the measurement results of the indicator bacteria inhibition zone in Example 1, Ex...

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Abstract

The invention provides a composition for preventing and treating candidiasis and medicine and feed additive containing the composition. The composition for preventing and treating candidiasis comprises plant essential oil, and the plant essential oil is composed of citrus oil, thyme oil, garlic oil and cinnamaldehyde; the composition for preventing and treating candidiasis also comprises plant extract, and the The plant extract is one or more of Ligustrum lucidum extract, Rosa japonica extract, Radish seed extract, Nutmegum extract, and Boluohui extract. The composition for preventing and treating candidiasis provided by the invention overcomes the drug resistance and safety problems caused by antifungal antibiotics such as nystatin and amphotericin B in use, and can effectively replace antibiotics in pigeon candidiasis The prevention and control effect is used for preparing natural medicines, feed additives, and drinking water administration. It is a safe product that can replace antibiotics, and has great application value in the healthy breeding of pigeons.

Description

technical field [0001] The invention relates to the technical field of medicine, and more particularly, to a composition for preventing and treating candidiasis albicans, and medicines and feed additives containing the composition. [0002] technical background [0003] Candida albicans is a common opportunistic fungus that can cause deep or superficial fungal infections in humans and animals. Mechanisms responsible for C. albicans virulence include adhesion / invasion molecules, hydrolases, biofilm formation, and yeast-to-hyphal transformation. Candida albicans can grow in the mouth, gastrointestinal tract and vagina, causing serious infections in millions of people worldwide. At present, the treatment of candidiasis mainly relies on the use of antifungal antibiotics such as nystatin and amphotericin B. However, the large-scale use of antibiotics will cause the drug resistance of Candida albicans in humans and animals, and the residual antibiotic residues will cause secondar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8962A61P31/10A23K20/158A23K20/105A23K10/30A61K31/11
CPCA61K36/752A61K36/53A61K36/8962A61K31/11A61K36/638A61K36/738A61K36/31A61K36/185A61K36/66A61P31/10A23K20/158A23K20/105A23K10/30A61K2300/00
Inventor 王占新胡文锋郭罕星祁姣姣鲁俊鹏覃健萍胡学生房向杰元波
Owner BIOFORTE BIOTECHNOLOGY (SHENZHEN) CO LTD
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