Perfluoropropane lipid microsphere for injection for angiography of cardiovascular diseases

A technology of perfluoropropane and lipid microspheres, which can be used in preparations for in vivo experiments, echo/ultrasonic imaging agents, pharmaceutical formulations, etc., can solve the problems of lack of stability, tolerance and safety, and achieve safety Well tolerated, well tolerated and highly safe effects

Pending Publication Date: 2020-11-13
HUBEI JIDENGFENG BIOTECH
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Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a perfluoropropane lipid microsphere for injection for angiography of cardiovascular diseases, which has the advantages of high stability, good tolerance and high safety, and solves the problem of existing injection The lack of stability, tolerance and safety of perfluoropropane lipid microspheres

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  • Perfluoropropane lipid microsphere for injection for angiography of cardiovascular diseases
  • Perfluoropropane lipid microsphere for injection for angiography of cardiovascular diseases

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Embodiment Construction

[0019] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0020] A perfluoropropane lipid microsphere for injection used for cardiovascular disease imaging, its preparation method is as follows:

[0021] Weigh a certain amount of DPPC, DPPA, Span 60 and Tween 80, and a small amount of PBS, mix and grind thoroughly, dilute the PBS to 250ml, apply it to an ultrasonic disperser for 30 minutes, fill it with nitrogen for 2 minutes, and then seal the system. Fill the system with perfluoropropane gas for 2 minutes (flow rate 1ml / s), dispers...

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Abstract

The invention discloses a perfluoropropane lipid microsphere for injection for angiography of cardiovascular diseases. The preparation method comprises the following steps of: weighing a certain amount of DPPC, DPPA, span 60, Tween 80 and a small amount of PBS, fully mixing and grinding, diluting PBS to 250ml, acting by an ultrasonic dispersion instrument for 30min, introducing nitrogen for 2min,sealing the system, filling perfluoropropane gas into the system for 2 minutes (the flow is 1ml / s), and performing high-shear dispersion at different speeds and action time when a dispersion tool bitextends into the liquid level to obtain a white uniform emulsion. The invention belongs to the technical field of radiography. OFP gas contained in the perfluoropropane human serum albumin microsphereinjection is completely eliminated from the lung in a prototype, and is not accumulated in vivo or metabolized in vivo; 2, the OFP is detected by adopting a GC-MS method, so that the method has the characteristics of accuracy, sensitivity and precision, and can fully meet the requirements of experiments; and 3, the medicine is safe and good in tolerance under the condition of reagent dosage.

Description

technical field [0001] The invention relates to the technical field of cardiovascular angiography, in particular to a perfluoropropane lipid microsphere for injection used for angiography of cardiovascular diseases. Background technique [0002] Contrast-enhanced ultrasound is widely used in early cardiovascular diagnosis and general cardiac function evaluation. The first-generation ultrasound contrast agents are air microbubbles. Due to poor stability, short clinical duration, weak enhancement effect, and little application value, and most of its film-forming materials are human albumin, there is a possibility of spreading diseases such as AIDS. The second and third generations of ultrasound contrast agents began to use fluorocarbon gas instead of air as the gas material. Membrane materials use liposomes, proteins, or polymers of sub-micron size. Due to the extremely low solubility of fluorocarbon gas in water, the monolayer membrane composed of liposomes is arranged regu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22
CPCA61K49/223
Inventor 洪峰
Owner HUBEI JIDENGFENG BIOTECH
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