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Implant material and implant suitable for bone defect and spinal fusion transplantation and preparation method thereof

An implant material and bone defect technology, applied in the field of implants, can solve the problem of difficulty in adapting to the microenvironment of the injury site and orderly regulating the repair process, unfavorable osteoblast migration and colonization, and lack of intelligent fine adjustment process in the osteogenic repair process, etc. problem, to achieve the effect of intelligence and precision

Pending Publication Date: 2020-11-13
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing graft materials are monolithic structures without regional characteristics, and it is difficult to adapt to the microenvironment of different regions of the injury site and to regulate the repair process in an orderly manner, so there are still limitations in the effect of promoting osteogenesis
Especially in the central area of ​​the graft material, because it is far away from the bone tissue and lacks the corresponding osteogenic microenvironment, the hypoxic environment formed by the material is not conducive to the migration of osteoblasts to the central area to colonize and differentiate to form new bone tissue and the corresponding bone trabecular structure , there is a lack of intelligent fine-tuning process for the microenvironmental response of the injury site and the osteogenic repair process

Method used

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  • Implant material and implant suitable for bone defect and spinal fusion transplantation and preparation method thereof
  • Implant material and implant suitable for bone defect and spinal fusion transplantation and preparation method thereof
  • Implant material and implant suitable for bone defect and spinal fusion transplantation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] prepared as figure 2 Fillers shown in implants suitable for spinal fusion implants.

[0044] 1. Prepare the first filling material.

[0045] 1.1 Construct bone-promoting biological glass-loaded protein molecules by chemical reaction of phosphate groups of nucleic acid molecules.

[0046] The ingredients are: biological glass loaded with osteogenesis-angiogenesis-related regulatory protein VEGF (10ng / ml) and cell chemotaxis regulation-related proteins such as MCP1 (2ng / ml).

[0047] 1.2 Preparation of gelMA double network self-healing hydrogel system.

[0048] The ingredients are: gelatin methacrylate, oxidized dextran, gelatin, and photoinitiator Irgacure 2959, which are respectively dissolved in PBS and mixed and stirred evenly. The final concentration ratio (w / v) is 12% gelatin methacrylate, oxidized glucose Polysaccharide 4%, gelatin 5%, photoinitiator 0.3%.

[0049] 1.3 Mix and crosslink the bioglass prepared in step 1.1 with the self-healing hydrogel prepared ...

Embodiment 2

[0068] To prepare fillers suitable for lumbar fusion implantation, the shape of which can be adopted figure 1 Filler shapes shown.

[0069] This example has the same partition form as Example 1, but the external shape is different, and the composition ratio of the material load in some areas is different. According to figure 1 Prepared as indicated.

[0070] 1. Prepare the first filling material.

[0071] 1.1 Construct bone-promoting biological glass-loaded protein molecules by chemical reaction of phosphate groups of nucleic acid molecules.

[0072] The ingredients are: biological glass loaded with osteogenesis-angiogenesis-related regulatory protein VEGF (10ng / ml) and cell chemotaxis regulation-related proteins such as TIMP1 (2ng / ml).

[0073] 1.2 Preparation of gelMA double network self-healing hydrogel system.

[0074] The ingredients are: gelatin methacrylate, oxidized dextran, gelatin, and photoinitiator Irgacure 2959, which are respectively dissolved in PBS and mixe...

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Abstract

The invention discloses an implant material suitable for bone defect and spinal fusion transplantation, an implant and a preparation method. The implant material is used for filling an inner cavity ora bone defect part of a titanium metal cage bracket, and is composed of an upper layer, a lower layer and a middle layer located between the upper layer and the lower layer. The middle layer is composed of an annular wrapping area located on the periphery and a central area located in the annular wrapping area; the central area is filled with a first filling material, and the first filling material is a gel material with an osteogenesis promoting effect; the annular wrapping area is filled with a second filling material, and the second filling material is a gel material with an epigenetic regulation effect; the upper layer and the lower layer are filled with a third filling material, and the third filling material is a gel material with the effects of regulating immune inflammation and stress reaction. The implant disclosed by the invention can adapt to microenvironments of different areas of a damaged part and orderly adjust the repair process, and is suitable for bone defect and spinal fusion transplantation.

Description

technical field [0001] The invention relates to the technical field of grafts used in bone defect transplantation and spinal fusion operations. Background technique [0002] The surgical graft materials currently used for bone defect transplantation and spinal fusion surgery usually use a hollow metal structure frame (titanium metal cage frame) to fill autologous bone fragments or other allogeneic bone-forming materials, or directly use autologous or allogeneic bone blocks supplemented with Osteogenic material transplantation fills the middle part of the defect to fill the dispersed autologous bone tissue or other allogeneic osteogenic materials during the operation. In recent years, due to the advancement of tissue engineering technology, a variety of materials have been used for bone defect and spinal fusion surgery transplantation, including hydroxyapatite, active bone cement and other components. [0003] Because the process of bone defect and spinal fusion repair needs...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/20A61L27/22A61L27/50A61L27/52A61L27/54A61F2/28A61F2/44
CPCA61L27/222A61L27/20A61L27/10A61L27/52A61L27/54A61L27/50A61F2/28A61F2/4455A61L2430/02A61L2300/252A61L2300/258A61L2300/414A61L2300/412A61F2002/2835C08L5/02
Inventor 邹学农易桦林陈珺王刚陈彦胡灏
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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