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A kind of antibacterial auxiliary material with bacteria conditioning properties and its preparation method and application

A technology of auxiliary materials and antibiotics, applied in the field of pharmacy, to achieve the effects of avoiding drug resistance, expanding antibacterial spectrum, and protecting toxic and side effects

Active Publication Date: 2022-05-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the toxic and side effects of antimicrobial peptides or nanosilver in these combined strategies are still worrying, and it will be of great significance to develop new non-antibiotic treatment strategies for combined treatment

Method used

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  • A kind of antibacterial auxiliary material with bacteria conditioning properties and its preparation method and application
  • A kind of antibacterial auxiliary material with bacteria conditioning properties and its preparation method and application
  • A kind of antibacterial auxiliary material with bacteria conditioning properties and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The above synthetic peptidomimetic was dissolved in 200 μL of dimethyl sulfoxide, 2 μL of D-mannose was added, and the mixture was shaken at 4° C. for 12 h.

Embodiment 2

Embodiment 3

[0038] The above synthetic peptidomimetic was dissolved in 200 μL of dimethyl sulfoxide, 2 μL of D-mannose was added, and the mixture was shaken at 4° C. for 12 h.

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PUM

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Abstract

The invention discloses an antibacterial auxiliary material with bacterium conditioning properties and its preparation method and application; the antibacterial auxiliary material is a natural opsonin protein, or an opsonoid complex formed by mimicking peptides and related materials that promote phagocytosis ; and the preparation and application of antibiotic prodrugs formed by chemically coupling antibiotics with antibacterial auxiliary materials, antibacterial auxiliary materials as prescription ingredients, and nano-preparations loaded with antibiotics. Antibiotic prodrugs are prepared from antibacterial auxiliary materials and antibiotics or their derivatives by mixed anhydride method or liquid phase synthesis. The antibacterial auxiliary material of the present invention can deliver the bacteria to the surface of the immune cells while targeting the adhered bacteria, activate the uptake of the immune cells, promote the phagocytosis of the bacteria by macrophages, and achieve the purpose of immune sterilization. Antibiotic prodrugs and antibiotic nano-preparations realize the combined treatment of antibiotic therapy and immune cell sterilization, and expand the antibacterial spectrum while improving the antibacterial efficacy.

Description

A kind of antibacterial auxiliary material with bacterial conditioning properties and preparation method and application thereof technical field The present invention relates to a kind of antibacterial auxiliary material with bacterial class conditioning characteristic and preparation method and application thereof, belong to The field of pharmaceutical technology. Background technique Antibiotics, as compounds that can kill or inhibit bacterial growth, make many of the compounds that have seriously endangered human life and health. Kang's infectious disease is under control. However, with the increasingly prominent problem of bacterial resistance, single antibiotic drug treatment It has been difficult to completely kill bacteria, and the rate of development of new antibiotics is slower than the rate at which bacteria develop resistance. Therefore, near Over the years, researchers have gradually turned their attention to how to target antibacterial drugs such as an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K38/17A61K38/10A61K38/16A61K47/54A61K47/55A61K47/34A61K9/107A61K9/127A61P31/04
CPCA61K39/39533A61K38/1732A61K38/10A61K38/16A61K47/549A61K47/557A61K47/545A61K47/55A61K47/34A61K9/1075A61K9/127A61P31/04Y02A50/30
Inventor 张文丽刘建平王亚杰刘欣悦
Owner CHINA PHARM UNIV
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