Novel molecular artemisinin derivative and synthesis method thereof

Abstract

The invention discloses a novel molecular artemisinin derivative and a preparation method thereof. The novel molecular artemisinin derivative comprises molecules formed by a chemical reaction of dihydroartemisinin and derivatives thereof (a) and flavonoid compounds (b). The compound (a) of dihydroartemisinin and derivatives thereof has molecular structures of dihydroartemisinin and derivatives thereof; in the reaction, dihydroartemisinin and liquiritin derivatives are used as initial raw materials, PPh3, and a DIAD reagent take THF a solvent, temperature is controlled at 0 DEG C, an etherification reactionis carried out under normal pressure to generate a target product (c); after the reaction, a reaction solution is washed, a target object is extracted (c) by using chloroform; desolventizing is carried out, a target object is dissolved by using ethyl acetate, and recrystallizing is carried out; and finally, desolventizing is carried out to obtain a white powder pure product, the effective ingredients of the product is analyzed and calibrated, and the validity and conversion rate of the experiment can be analyzed. According to the invention, the novel molecular artemisinin derivative is safer, does not cause serious side effects, can be used as a sensitizer of adjuvant chemotherapeutic drugs, and is beneficial to improving the anti-cancer effects of other chemotherapeutic drugs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new molecular artemisinin derivative and a preparation method thereof. [0002] technical background [0003] Many cancer treatment drugs have been found in the prior art, but all of these treatment methods will produce serious side effects or cause drug resistance. There are still few drugs that can effectively treat advanced or metastatic cancers (or cancers that usually develop metastases), and treatment options for these cancers are relatively limited. [0004] Dihydroartemisinin (DHA) is an artemisinin derivative with high-efficiency and low-toxic antimalarial activity. However, studies in recent years have shown that dihydroartemisinin and its derivatives also have various biological activities such as anti-tumor, anti-inflammation, and anti-fibrosis, and many studies have deeply explored the effects of artemisinin and its derivatives on various cancers. potential anticancer effe...

AI Technical Summary

Problems solved by technology

However, these derivatives have technical defects such as relatively single types, low anti-cancer activity, few types of anti-cancer types, insufficient targeting, and insignificant activation of the immune system. Carry out extended research on drugs, focus on solving these technical defects, and obtain more new anticancer drugs with anticancer activity and immune system activation mechanism

Images