Nano-emulsion based on dehydrated sorbitol fatty acid ester and application thereof

Abstract

A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C); (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid . A nanoemulsion comprising a dispersed lipid phase in an aqueous phase with the lipid globules having an average size of less than 100 nm contains: (1) a surfactant (solid at up to 45 degrees C) such as sorbitan fatty esters optionally oxyethylenated; (2) at least one oil with a molecular weight of more than 400; and (3) at least one ionic amphiphilic lipid such as alkaline salts of dicetyl- and dimyristylphosphate, alkaline salts of cholesterol sulfate or phosphate, lipoaminoacids, sodium salts of phosphatidic acid, cationic amphiphilic lipid or alkylsulfonic derivatives at a lipid phase / surfactant weight ratio of 2-10. Independent claims are also included for: (1) a topical composition comprising the above described composition; (2) an ophthalmic support comprising the above described composition; (3) a pharmaceutical composition comprising the above described composition; (4) a cosmetic method for the care and / or hydration of the skin, mucosa and / or scalp by applying the above described composition; and (5) the preparation of the composition by mixing an aqueous phase and a lipid phase at 10-80 degrees C and homogenizing the mixture at 6 x 10<7>-18 x 10<7> Pa.

Description

technical field [0001] The present invention relates to a nanoemulsion based on a surface selected from the group consisting of sorbitan fatty acid esters and oxyethylated sorbitan fatty acid esters, which are solid at temperatures below or equal to 45°C Active agent, at least one oil with a molecular weight greater than 400 and at least one ionic amphoteric lipid, the weight ratio of oil phase content to surfactant content is 2-10. [0002] The present invention also relates to a method for preparing the aforementioned nanoemulsion and its use in the fields of cosmetics, dermatology and / or ophthalmology. The emulsion is stable to storage and can contain high amounts of oil while maintaining good clarity and cosmetic properties. Background technique [0003] Nanoemulsions are oil-in-water emulsions whose oil droplets have a very fine particle size, that is to say, a number average particle size of less than 100 nm. It is usually made by mechanica...

AI Technical Summary

Problems solved by technology

However, a disadvantage of this nanoemulsion is the sticky feel when applied to the skin