Hydrophilic ultra-smooth coating for surface of medical catheter guide wire and preparation method of hydrophilic ultra-smooth coating

Abstract

The invention discloses a hydrophilic ultra-smooth coating for the surface of a medical catheter guide wire. The hydrophilic ultra-smooth coating comprises a bottom layer coating and a surface layer coating, wherein the bottom layer coating is formed by controllable catalytic polymerization of dopamine or derivatives thereof in the presence of an oxidant and a first organic solvent. The preparation method comprises the following steps: step 1, preparing a bottom layer coating paint: under a dark condition, adding a first organic solvent into a container, respectively adding dopa or dopamine derivatives while stirring to prepare a solution A, adding a strong oxidant while stirring to prepare a solution B, and performing uniform stirring to obtain a uniform and transparent solution. According to the invention, a double-layer coating system is constructed, the bottom layer is used as a middle connecting layer, has broad-spectrum strong adhesion performance and is firmly attached to a basematerial, so that on one hand, the bottom layer can be subjected to chemical reaction with functional groups in the surface layer coating to form covalent bonds, and the surface layer can be firmly fixed on the bottom layer. Therefore, the hydrophilic coating has excellent biocompatibility, lubricity and durability.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a hydrophilic super-slip coating used on the surface of a guide wire of a medical catheter and a preparation method thereof. Background technique [0002] In the medical field, interventional medicine has become a very important minimally invasive means. Interventional medical devices, especially catheters and guide wires, require their surfaces to have good biocompatibility and lubricity, so as to greatly reduce the damage or adhesion to the patient's body tissues. At present, there are many ways to solve the problem of lubricity, such as coating the surface of the device with lubricating oil, but the biocompatibility of the medical device obtained by this method is poor, and the lubricity and durability cannot meet the operating standards. In addition, there is a method of directly preparing a catheter with a super-lubricating surface, but the surface lubricity of the ...

AI Technical Summary

Problems solved by technology

At present, there are many ways to solve the problem of lubricity, such as coating lubricating oil on the surface of the device, but the biocompatibility of the medical device obtained by this method is poor, and the lubricity and durability cannot meet the operating standards

In addition, there is a method of directly preparing a catheter with a super-lubricating surface, but the surface lubrication performance of the catheter and guide wire obtained by the existing extrusion technology is still not good, and cannot meet the super-smooth standard.

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