Application of fructus gardeniae extract in preparation of drugs for treating ulcerative colitis
A technology of ulcerative colitis and gardenia extract, which is applied in the field of application of gardenia extract in the preparation of medicines for treating ulcerative colitis, and can solve problems that have not yet been seen
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Embodiment 1
[0023] Gardeniae is crushed into a coarse powder (20 mesh), 1000g is taken and placed in an extraction tank, and 70v / v% ethanol is added to reflux extraction for 2 times (the addition of the solvent is respectively 8 times the weight of Gardenia and 5 times the amount, and the extraction time for both times is 2 hours); combine the extracts, filter, and concentrate the filtrate to the extract (without alcohol smell) to obtain the extract; add water to the obtained extract to form a suspension, and put it on the HPD600 macropore Resin column (resin consumption is 10 times of the extract weight, and the adsorption flow rate is 2BV / h), first eluted with water of 8 times of column volume, then eluted with 35v / v% ethanol of 4 times of column volume, and collected 35v / v The v% ethanol eluted part was concentrated under reduced pressure until it had no alcohol smell, and then freeze-dried to obtain 70 g of gardenia extract.
[0024]Accurately weigh 0.2g of the gardenia extract prepar...
Embodiment 2
[0026] Grind gardenia into coarse powder (20 mesh), take 1000g and put it in an extraction tank, add 80v / v% methanol to reflux and extract 3 times (the amount of solvent added during each extraction is respectively 10 times the weight of gardenia) , 8 times the amount and 5 times the amount, the 3 times of extraction time were respectively 2 hours, 1.5 hours and 1 hour); the combined extracts were filtered, and the filtrate was concentrated to the extract (no alcohol smell) to obtain the extract; the obtained Add water to the extract to form a suspension, put it on a D101 macroporous resin column (the amount of resin is 8 times the weight of the extract, and the adsorption flow rate is 2BV / h), first elute with 6 times the column volume of water, and then use 3 times the column volume 50v / v% ethanol was eluted, and the 50v / v% ethanol eluted part was collected, concentrated under reduced pressure until no alcohol smell, and then freeze-dried to obtain 75g of gardenia extract.
Embodiment 3
[0028] Gardeniae is crushed into coarse powder (40 mesh), 1000g is taken and placed in an extraction tank, and 50v / v% n-alcohol is added for reflux extraction for 2 times (the amount of solvent added during each extraction is 8 times the weight of Gardeniae, The two extraction times are 2 hours and 1 hour respectively); the extracts are combined, filtered, and the filtrate is concentrated to the extract (without alcohol smell) to obtain the extract; the obtained extract is added with water to form a suspension, and the AB-8 Macroporous resin column (resin consumption is 10 times of the weight of the extract, and the adsorption flow rate is 2BV / h), first eluted with water of 8 times of column volume, then eluted with 40v / v% ethanol of 3 times of column volume, collected The part eluted with 50v / v% ethanol was concentrated under reduced pressure until there was no alcohol smell, and then freeze-dried to obtain 72g of gardenia extract.
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