Bionic nano-carrier as well as preparation method and application thereof

A biomimetic nano-carrier technology, applied in nano-technology, nano-drugs, nano-technology, etc., can solve the problems of short blood circulation time and no sustained-release effect, so as to improve the absorption capacity, improve the anti-tumor effect, high-depth penetration and The effect of internalizing ability

Active Publication Date: 2020-12-18
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, the blood circulation time of the nanoparticles is short, and there is almost no sustained release effect

Method used

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  • Bionic nano-carrier as well as preparation method and application thereof
  • Bionic nano-carrier as well as preparation method and application thereof
  • Bionic nano-carrier as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of biomimetic nanocarriers (Comb-m-NPs):

[0062] (1) Slowly add 40mL of ethylenediamine solution (1.4mol / L, pH=4.75) dropwise into 5mL of bovine serum albumin solution (10%, m / v) under constant stirring, and then slowly add the catalyst in batches several times 1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCL) 30mg, react at room temperature for two hours, add 400μL of acetate buffer (4mol / L, pH=4.75) The reaction was terminated, and then dialyzed for 48 hours, replaced every 24 hours to obtain a cationic polymer material.

[0063] (2) Take 100 mg of cationic polymer material and dissolve it in 10 mL of normal saline, take 10 mg of paclitaxel and dissolve it in 1 mL of ethanol, add paclitaxel ethanol solution into the water phase at 0.5 mL / min, supplemented by stirring to form colostrum. Then continue to stir for a period of time to volatilize most of the ethanol. After the system is stable, spin evaporate to remove the remaining ethanol,...

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Abstract

The invention discloses a bionic nano-carrier as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. According to the bionic nano-carrier, cationic nanoparticles entrapping a chemotherapeutic drug serve as an inner core, and surfaces of the cationic nanoparticles are coated with a hybrid cell membrane composed of an immune cell membrane and a tumor cell membrane to serve as a shell. The bionic nano-carrier is high in targeting property and strong in uptake capacity, can enhance anti-tumor curative effect, provides a new thought for individualized and accurate treatment, and has relatively high clinical practical significance.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a drug-loaded cationic biomimetic nanocarrier coated with immune cells and tumor cells and its application in preparing tumor-targeted therapeutic drugs. Background technique [0002] At present, many nanoparticles have been researched and developed as tumor drug delivery systems, some of which have been approved for clinical use, and most of them are still in different stages of clinical trials. This is because the tumor targeting efficiency of nanoparticles is low, especially chemotherapy drugs bring systemic toxic and side effects, which increases the physical and psychological burden of patients. The efficiency of nanoparticles in targeted drug delivery largely depends on the blood circulation time, the potential to accumulate and penetrate tumor tissue, and the final cellular internalization efficiency, the mononuclear phagocytic system (consi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/337A61K31/704A61K38/05A61K38/08A61K47/18A61K47/34A61K47/36A61K47/42A61P35/00B82Y5/00
CPCA61K9/5068A61K47/18A61K47/183A61K47/36A61K47/34A61K47/42A61K38/08A61K38/05A61K31/337A61K31/704A61P35/00B82Y5/00
Inventor 孙春萌涂家生徐慧
Owner CHINA PHARM UNIV
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