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Preparation method of freeze-dried liposome containing hair-growing composition

A technology of composition and liposome, which is applied in the field of preparation of freeze-dried liposome, can solve problems such as uneven particle size and poor stability, and achieve the effects of prolonging storage time, easy storage, and direct use

Active Publication Date: 2020-12-25
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liposomes are currently made into a freeze-dried state by freeze-drying technology. When two or more reagents are encapsulated at the same time, especially if the solubility characteristics of the reagents are different, the prepared freeze-dried liposomes have particle sizes Disadvantages such as inhomogeneity and poor stability

Method used

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  • Preparation method of freeze-dried liposome containing hair-growing composition
  • Preparation method of freeze-dried liposome containing hair-growing composition
  • Preparation method of freeze-dried liposome containing hair-growing composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for preparing freeze-dried liposomes containing a hair growth composition, comprising the steps of:

[0051] (1) According to the mass ratio of 1: 1: 0.5: 3, weigh 10 g biflavone, 10 g quercetin-3-o-rutinoside, 5 g tetramethylpyrazine, and 30 g ricinoleic acid to form hair growth The composition is for subsequent use, and 800 g of hyaluronic acid oligosaccharides and 160 g of sclerotin are weighed to form a lyoprotectant for subsequent use according to a mass ratio of 1:0.2;

[0052] (2) Weigh 55 g of the hair growth composition obtained in step (1), 220 g of cholesterol and 110 g of hydrogenated lecithin in a mass ratio of 1:4:2. Take 1 kg of ethanol solution, completely dissolve the hair growth mixture in ethanol solution, then sonicate at a temperature of 40°C, ultrasonic time for 5 min, and ultrasonic power of 200 W, let it stand for 20 min, and then °C water bath temperature, vacuum degree 0.001 MPa, rotation speed 50 rpm, rotary evaporation under reduced...

Embodiment 2

[0057] A method for preparing freeze-dried liposomes containing a hair growth composition, comprising the steps of:

[0058] (1) According to the mass ratio of 1: 2: 1: 4, weigh 10 g Biflavone, 20 g quercetin-3-o-rutinoside, 10 g tetramethylpyrazine, and 40 g ricinoleic acid Make the composition for subsequent use, and take 120 g of hyaluronic acid oligosaccharides and 36 g of sclerotin to form the lyoprotectant for subsequent use according to the mass ratio of 1: 0.3;

[0059] (2) Weigh 80 g of the hair growth composition obtained in step (1), 800 g of cholesterol and 400 g of hydrogenated lecithin at a mass ratio of 1:10:5. Take 3.3 kg of ethanol solution, completely dissolve the hair growth mixture in the ethanol solution, then sonicate at a temperature of 42°C, an ultrasonic time of 8 min, and an ultrasonic power of 240 W. °C water bath temperature, vacuum degree 0.001 MPa, rotation speed 80 rpm under reduced pressure and rotary evaporation to remove the solvent, and then...

Embodiment 3

[0064] A method for preparing freeze-dried liposomes containing a hair growth composition, comprising the steps of:

[0065] (1) According to the mass ratio of 1: 2: 2: 3.5, weigh 20 g of Biflavone, 40 g of quercetin-3-o-rutinoside, 40 g of tetramethylpyrazine, and 70 g of ricinoleic acid to form hair growth The composition is for subsequent use, and 15 kg of hyaluronic acid oligosaccharides and 6 kg of sclerotin are weighed to form a lyoprotectant for subsequent use according to the mass ratio of 1:0.4;

[0066] (2) Weigh 170 g of the hair growth composition obtained in step (1), 3400 g of cholesterol and 1700 g of hydrogenated lecithin at a mass ratio of 1:20:10. Take 13.7 kg of ethanol solution, completely dissolve the hair growth mixture in ethanol solution, and then sonicate at a temperature of 43°C, an ultrasonic time of 9 min, and an ultrasonic power of 280 W; °C water bath temperature, vacuum degree 0.006 MPa, rotating speed 70 rpm under reduced pressure and rotary ev...

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Abstract

The invention relates to a preparation method of a freeze-dried liposome containing a hair-growing composition. The preparation method is characterized by comprising the following steps: A, weighing amentoflavone, quercetin-3-o rutinoside, tetramethylpyrazine and ricinoleic acid according to a mass ratio of 1: (1-3): (0.5-2): (3-5) to form the hair-growing composition, and weighing hyaluronic acidoligosaccharide and scleroglucan according to a mass ratio of 1: (0.2-0.5) to form a freeze-drying protective agent; B, dissolving the hair-growing composition, cholesterol and hydrogenated lecithinin ethanol, performing ultrasonic treatment, and performing reduced-pressure rotary evaporation to remove ethanol to obtain a lipid membrane containing the hair-growing composition; C, adding an isotonic phosphate buffer solution into the lipid membrane, and performing ultrasonic treatment and filtration to obtain a liposome suspension; and D, adding the freeze-drying protective agent into the liposome suspension, and performing vacuum freezing at the temperature of minus 50 DEG C to minus 10 DEG C for 36-72 hours to obtain the freeze-dried liposome containing the hair-growing composition. Thefreeze-dried liposome containing the hair-growing composition has the advantages of uniform particle size, high stability, convenience in use and good hair-growing effect.

Description

technical field [0001] The invention relates to the technical field of liposome preparation, in particular to a preparation method of freeze-dried liposome containing hair growth composition. Background technique [0002] The causes of hair loss mainly include the following aspects, (1) seborrheic alopecia caused by excessive oil secretion due to low physiological function of hair follicles, hair bulbs and hair; (2) local blood circulation disorder and nutritional deficiency caused by scalp tension, resulting in Hair loss; (3) Androgenetic alopecia caused by excessive androgen acting on hair follicles and dermal papilla, resulting in slowing down of dermal papilla division; (4) Bacterial infection, genetic factors, pathological factors, injury factors, mental factors and other causes . [0003] There are a wide variety of hair growth and development products sold on the market, and their modes of action are mainly divided into two categories. One is chemical interference h...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/365A61K8/14A61K8/60A61P17/14A61Q7/00
CPCA61K8/498A61K8/494A61K8/365A61K8/602A61K8/14A61Q7/00A61P17/14A61K2800/84
Inventor 李欣航涂静平杜正芳张丙楠陈静毕永贤蒋丽刚
Owner PROYA COSMETICS
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