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Casein-based dual-network antibacterial composite hydrogel material and preparation method thereof

A composite hydrogel and casein technology is applied in the field of polymer biomaterial preparation, which can solve the problems of easy mildew and spoilage, poor antibacterial performance, etc., and achieve the effects of excellent hygienic performance, stable performance and wide application prospects.

Active Publication Date: 2020-12-25
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a natural substance, casein usually has problems such as mildew and corruption, poor antibacterial performance, etc.

Method used

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  • Casein-based dual-network antibacterial composite hydrogel material and preparation method thereof
  • Casein-based dual-network antibacterial composite hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The mass of the prepared casein-based double network composite hydrogel is 100 parts, in parts by mass.

[0030] Step 1: Take a certain amount of deionized water, use triethanolamine to adjust pH=10; add 1.25 parts by mass of casein powder to 98.65 parts by mass of triethanolamine solution, mix and add to a three-necked flask and continue stirring with a stirrer, and heat in a water bath to The temperature is 45°C, the magnetic stirring speed is controlled at 500 r / min, and the stirring is continued for 1 h until it dissolves to obtain a casein dispersion;

[0031] Step 2: Take 0.10 parts by mass of zinc oxide nanoparticles and add them into deionized water, and magnetically stir at room temperature until they are uniformly dispersed to obtain a zinc oxide dispersion. Slowly add it to the casein dispersion while stirring, and ultrasonically react at 45°C for 1 h, so that the nano-zinc oxide is evenly dispersed between the casein molecules, and a mixed dispersion is obta...

Embodiment 2

[0034] The mass of the prepared casein-based double network composite hydrogel is 100 parts, in parts by mass.

[0035] Step 1: Take a certain amount of deionized water, use triethanolamine to adjust pH=10; add 1.35 parts by mass of casein powder to 98.40 parts by mass of triethanolamine solution, mix and add to a three-necked flask and continue stirring with a stirrer, and heat in a water bath to The temperature is 45°C, the magnetic stirring speed is controlled at 500 r / min, and the stirring is continued for 1 h until it dissolves to obtain a casein dispersion;

[0036] Step 2: Take 0.25 parts by mass of zinc oxide nanoparticles and add them into deionized water, and magnetically stir at room temperature until they are uniformly dispersed to obtain a zinc oxide dispersion. Slowly add it to the casein dispersion while stirring, and ultrasonically react at 45°C for 1 h, so that the nano-zinc oxide is evenly dispersed between the casein molecules, and a mixed dispersion is obtain...

Embodiment 3

[0039] The mass of the prepared casein-based double network composite hydrogel is 100 parts, in parts by mass.

[0040] Step 1: Take a certain amount of deionized water, use triethanolamine to adjust pH=10; add 1.45 parts by mass of casein powder to 98.15 parts by mass of triethanolamine solution, mix and add to a three-necked flask and continue stirring with a stirrer, and heat in a water bath to The temperature is 45°C, the magnetic stirring speed is controlled at 500 r / min, and the stirring is continued for 1 h until it dissolves to obtain a casein dispersion;

[0041] Step 2: Take 0.40 parts by mass of zinc oxide nanoparticles and add them into deionized water, and magnetically stir at room temperature until they are uniformly dispersed to obtain a zinc oxide dispersion. Slowly add it to the casein dispersion while stirring, and ultrasonically react at 45°C for 1 h, so that the nano-zinc oxide is evenly dispersed between the casein molecules, and a mixed dispersion is obta...

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Abstract

The invention discloses a casein-based dual-network antibacterial composite hydrogel material and a preparation method thereof. The preparation method includes the steps that: casein serves as a basematerial, zinc oxide nanoparticles are introduced, casein dispersion liquid and the zinc oxide nanoparticles are evenly mixed through physical blending; metal ions are used as a cross-linking agent topromote the casein to be complexed and cross-linked in a self-crosslinking structure to form a double-network structure; part of the zinc oxide nanoparticles are coated and dispersed in hydrogel in the form of an antibacterial agent, and the casein-based double-network antibacterial composite hydrogel is obtained through UV photocuring. The casein-based dual-network composite hydrogel is obtainedby utilizing the advantages of unique amphipathy, good swelling property, wide source, low price and the like of the casein, and has the advantages of high reaction rate and stable structure. According to the prepared casein-based dual-network composite hydrogel, nanoparticles are uniformly dispersed and effectively cross-linked between casein micelles, so that the hydrogel is green and environment-friendly, has stable performance and has antibacterial property.

Description

technical field [0001] The invention belongs to the technical field of polymer biomaterial preparation, and in particular relates to a casein-based double-network antibacterial composite hydrogel material and a preparation method thereof. Background technique [0002] Hydrogels are water-soluble polymers with three-dimensional networks capable of trapping large amounts of water within their structures. The porous structure of hydrogels makes them excellent materials for protection and transportation. Hydrogels have the following characteristics: (1) Water-swellable, cross-linked polymers. (2) Hydrophilic, absorbing water up to thousands of times its own weight. (3) Three-dimensional network structure, insoluble in water. (4) Ability to perceive small external stimuli. Hydrogel properties depend on polymer concentration, degree of crosslinking, temperature, pH, aging and salt concentration. [0003] Casein is a kind of globular protein that can be completely biodegradabl...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/28C08J3/24C08L89/00C08K3/22C08K3/08
CPCC08J3/075C08J3/28C08J3/243C08J2389/00C08K2003/2296C08K2201/011C08K2003/0806
Inventor 徐群娜杨羽西崔天雨
Owner SHAANXI UNIV OF SCI & TECH
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