Unlock instant, AI-driven research and patent intelligence for your innovation.

Sea urchin thorn-like continuous gradient change biological scaffold and application thereof

A bio-scaffold and gradient change technology, applied in bone implants, metal processing equipment, manufacturing tools, etc., can solve the problems of high cell seeding efficiency and mass transfer capacity at the same time, and improve cell seeding efficiency and elastic modulus The effect of high and low elastic modulus

Active Publication Date: 2021-01-05
HUAZHONG UNIV OF SCI & TECH
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is necessary to design a new bioscaffold to solve the technical problem that the traditional lattice structure design cannot satisfy high cell planting efficiency, high mass transfer capacity and adapted porosity at the same time.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sea urchin thorn-like continuous gradient change biological scaffold and application thereof
  • Sea urchin thorn-like continuous gradient change biological scaffold and application thereof
  • Sea urchin thorn-like continuous gradient change biological scaffold and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute a conflict with each other.

[0034] see figure 1 and Figure 5A ~ Figure 5C , the present invention provides a bioscaffold that imitates sea urchin-shaped continuous gradient changes, and the bioscaffold includes a plurality of unit cell structures connected layer by layer (such as figure 1 shown), the shape of each unit cell structure is a Diamond structure formed by connecting multiple rods 2, and the diameter of each r...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the related technical field of biological scaffolds, and discloses a sea urchin thorn-like continuous gradient change biological scaffold and application thereof. The biological scaffold comprises a plurality of unit cell structures connected layer by layer, and each unit cell structure is in the shape of a Diamid structure formed by connecting a plurality of rod pieces. The diameter of each rod piece changes in a gradient mode from the middle to the two ends, so that each rod piece is in an outwards-convex shuttle shape or an inwards-concave double-horn shape. The surface area of the biological scaffold can be increased, the cell seeding efficiency can be improved, the tortuosity in the biological scaffold can be increased, the contact time of nutrient substance transmission and the scaffold can be prolonged, and the mass transfer capacity of the biological scaffold and the matching degree with external bones can be improved.

Description

technical field [0001] The invention belongs to the technical field related to biological scaffolds, and more specifically relates to a biological scaffold imitating sea urchin thorns with continuous gradient changes and applications thereof. Background technique [0002] With the development of bioengineering technology, the medical field has put forward urgent needs and requirements for bioscaffolds of surgical bone implants or bone substitutes. At present, most biological scaffold structures are designed using traditional lattice structures. There is a strong coupling relationship between the relative density of the traditional lattice structure and the mechanical properties and mass transfer performance, which makes it difficult to balance the cell planting efficiency, mass transfer capacity and porosity. Where the porosity is low, such as the cancellous bone area, the surface area of ​​the scaffold designed by the traditional lattice structure is low, thereby reducing ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
CPCA61F2/28A61F2/2846A61F2002/2835A61F2002/30985
Inventor 宋波张磊史玉升
Owner HUAZHONG UNIV OF SCI & TECH