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Preparation method of rhodiola rosea extract

A technology of Rhodiola rosea and extract, applied in the biological field, can solve the problems of low sample yield, complicated operation, unsuitable for industrial production, etc.

Inactive Publication Date: 2021-01-15
江苏芝能生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complicated operation, small amount of preparation and low sample yield, it is not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Crush the rhodiola raw material dried at 60°C, pass through a 60-mesh sieve, put the resulting coarse powder in a container, add 5 times the amount of 50% ethanol solution, and put the container into a constant temperature water bath at 70°C Extract for 90 minutes, place the obtained extract in ultrasonic extraction with a frequency of 20KHz for 3 times, each time for 15 minutes, concentrate the extract under reduced pressure to recover ethanol, and concentrate it into an extract. The obtained extract is dissolved in heated water and suction filtered. And add activated carbon with a mass volume ratio of 1:15 to decolorize to obtain a crude extract, absorb the crude extract on a D101 macroporous resin column, elute with 3 times the column volume and 30% ethanol aqueous solution, collect the eluate and concentrate in vacuo Made of rhodiola rosea extract crystals.

Embodiment 2

[0014] Grind the rhodiola rosea raw material dried at 70°C, pass through a 80-mesh sieve, put the obtained coarse powder in a container, add 8 times the amount of 60% ethanol solution, and put the container into a constant temperature water bath at 70°C Extracted for 100min, put the obtained extract into 30KHz ultrasonic extraction for 3 times, each time for 20min, the extract was concentrated under reduced pressure to recover ethanol, and concentrated into an extract, the obtained extract was dissolved in heated water and suction filtered, and added mass Activated carbon with a volume ratio of 1:20 was decolorized to obtain a crude extract, which was adsorbed on an LSA-21 macroporous resin column, eluted with 5 times the column volume and 40% ethanol aqueous solution, and the eluate was collected and concentrated in vacuo to prepare into rhodiola extract crystals.

Embodiment 3

[0016] Grind the rhodiola rosea raw material dried at 80°C, pass through a 80-mesh sieve, put the resulting coarse powder in a container, add 10 times the amount of 70% ethanol solution, and put the container into a constant temperature water bath at 70°C Extract for 120min, place the obtained extract in ultrasonic extraction with a frequency of 40KHz for 3 times, concentrate the extract under reduced pressure for 30min each time to recover ethanol, and concentrate it into an extract. The obtained extract is dissolved in heated water and suction filtered. Add activated carbon with a mass volume ratio of 1:30 to decolorize the crude extract, absorb the crude extract on a HZ816 macroporous resin column, elute with 6 times the column volume and 50% ethanol aqueous solution, collect the eluent and concentrate it in vacuo to prepare into rhodiola extract crystals.

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Abstract

The invention discloses a preparation method of a rhodiola rosea extract. The method comprises the following steps of crushing a rhodiola rosea raw material dried at 55-80 DEG C, performing sieving with a 55-80-mesh sieve, putting obtained coarse powder into a container, adding a 40-70% ethanol solution with the amount 5-10 times that of the coarse powder, putting the container into a constant-temperature water bath kettle with the temperature of 70 DEG C, performing extraction for 90-120 minutes, putting obtained extract into an ultrasonic extraction device, performing ultrasonic extraction for 2-3 times, performing reduced pressure concentration on extracting liquid, recovering the ethanol, performing concentration to be in the shape of extractum, adding hot water to dissolve the obtained extractum, carrying out suction filtration, adding activated carbon with the mass-volume ratio of 1:(15-30), performing decolorization to obtain crude extracting liquid, adsorbing the crude extracting liquid with a macroporous resin column, performing elution with a 25-50% ethanol aqueous solution, collecting an eluent, and carrying out vacuum concentration to obtain the rhodiola rosea extract.The method is adopted for preparing the rhodiola rosea extract, and is simple and convenient in technological operation, high in yield, small in pollution and suitable for production of the high-purity rhodiola rosea extract.

Description

technical field [0001] The invention particularly relates to a preparation method of a rhodiola rosea extract, which belongs to the field of biotechnology. Background technique [0002] Rhodiola rosea (Rhodiola rosea) is a perennial herb of the Sedum family Rhodiola genus. It has pharmacological activities such as sleeping and calming, hypoxia resistance, anti-aging, and anti-radiation. Ginseng and Acanthopanax have a long history of clinical application in Chinese medicine. This medicinal material contains active ingredients such as salidroside and tyrosol, and has significant anti-oxidation and anti-tumor pharmacological activities. In recent years, there have been a large number of reports on its pharmacological effects at home and abroad. However, due to the limitations of the current extraction technology development, the traditional extraction technology has certain shortcomings in terms of extraction efficiency and post-extraction activity. [0003] According to lit...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61P25/20A61P39/00A61P39/06A61P35/00
CPCA61K36/41A61K2236/333A61K2236/51A61K2236/53A61P25/20A61P35/00A61P39/00A61P39/06
Inventor 杨成东
Owner 江苏芝能生物科技有限公司
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