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Combined medicine for treating malignant tumors

A technology for malignant tumors and drugs, applied in the field of combined drugs for the treatment of cancer, can solve problems such as affecting drug efficacy and body intolerance, and achieve the effects of improving drug efficacy, reducing phagocytosis, and inhibiting autophagy.

Pending Publication Date: 2021-01-15
GUANGZHOU SINOGEN PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a combined drug for treating malignant tumors, to overcome the problem of body intolerance caused by the high concentration of genetically engineered bacteria used alone and affecting the effect of the drug, the method is safe and non-toxic, and Possesses anti-tumor effects and can meet clinical needs

Method used

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  • Combined medicine for treating malignant tumors
  • Combined medicine for treating malignant tumors
  • Combined medicine for treating malignant tumors

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Embodiment

[0020] A combined drug for treating malignant tumors, comprising the combined use of attenuated Salmonella typhimurium VNP20009 cloned with a methioninase (L-methioninase) gene and chloroquine phosphate.

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Abstract

The invention provides a combined medicine for treating malignant tumors. The combined medicine contains unit preparations with different specifications and is used for simultaneously or respectivelysupplying genetically engineered bacteria and chloroquine diphosphate salt. The combined medicine disclosed by the invention can be used for effectively treating cancers, and the effect is obviously superior to that of single use of the genetically engineered bacteria and the chloroquine diphosphate salt, so that the genetically engineered bacteria and the chloroquine diphosphate salt have an obvious synergistic effect after cooperating for use, have strong anti-tumor activity and small side effects, and provide a new treatment direction for patients who lose operation indications clinically,cannot be operated and have poor radiotherapy and chemotherapy effects.

Description

technical field [0001] The invention relates to a combination medicine for treating cancer, in particular to a combination medicine for treating malignant tumors. Background technique [0002] Malignant tumor is a common disease that seriously threatens human life and health. According to the latest statistics in 2015, the mortality rate of malignant tumors accounts for 23.91% of all deaths among residents. In the past 10 years, the incidence of malignant tumors in China has maintained an annual increase of 3.9%, and the mortality rate has maintained an annual increase of 2.5%. That is, an average of more than 10,000 people per day, 7.5 people are diagnosed with cancer every minute. The medical expenses caused by malignant tumors exceed 220 billion, and the prevention and control situation is severe. At present, there are many means and methods for the treatment of malignant tumors, such as surgery, chemical drug therapy, radiation therapy, etc. These treatments have certa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/51A61P35/00A61K31/4706
CPCA61K31/4706A61K38/51A61P35/00C12Y404/01011A61K2300/00Y02A50/30
Inventor 赵子建李芳红周素瑾赖运浩赵正刚
Owner GUANGZHOU SINOGEN PHARMA CO LTD
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