Vesicles comprising a pten inhibitor and uses of same

An inhibitor, vesicle technology, applied in the field of treatment of spinal cord injury, can solve problems such as cascade effect efficiency
CN112236131APending Publication Date: 2021-01-15TECHNION RES & DEV FOUND LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TECHNION RES & DEV FOUND LTD
Publication Date
2021-01-15

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Abstract

The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphataseand tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.
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Description

technical field

[0001] The present invention relates to membranous vesicles loaded with PTEN inhibitors, pharmaceutical compositions comprising the vesicles, and their use in the treatment of neurological diseases, more particularly, to cell-derived vesicles loaded with exogenous PTEN inhibitors. Extracellular vesicles, pharmaceutical compositions comprising the vesicles, and their use for treating spinal cord injuries. Background technique

[0002] Spinal cord injury may result in autonomic dysfunction, loss of sensation, or loss of mobility. This spinal cord injury (SCI) is caused by trauma, tumor, ischemia, developmental disturbance, neurodegenerative disease, demyelinating disease, transverse myelitis, vascular malformation or other causes. The consequences of SCI depend on the specific nature of the injury and its location in the spinal cord. Furthermore, since SCI is a dynamic process, in all acute spinal cord syndromes the extent of injury may not be apparent initia...

Claims

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