Method for detecting fingerprint spectrum of medicinal preparation

A detection method and a technology of pharmaceutical preparations, which are applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of many medicinal flavors, inability to fully evaluate the internal quality, and inconformity with the holistic view of syndrome differentiation and treatment.

Active Publication Date: 2021-01-26
SHANDONG BUCHANG SHENZHOU PHARMA
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

However, because there are many medicinal flavors in the prescription of this medicinal preparation, if only one quantitative index of paeoniflorin is used, the internal quality of the medicinal cannot be fully evaluated.
It also does not conform to the holistic view of syndrome differentiation and treatment of multi-components and multi-targets in traditional Chinese medicine.

Method used

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  • Method for detecting fingerprint spectrum of medicinal preparation
  • Method for detecting fingerprint spectrum of medicinal preparation
  • Method for detecting fingerprint spectrum of medicinal preparation

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1 Instruments and reagents

[0041] Waters 2695-2998 high performance liquid chromatograph (Waters company); Chinese medicine chromatographic fingerprint similarity evaluation software (version 2012.130723); XSE205 1 / 100,000 electronic balance (METTLER company); BK-600C ultrasonic cleaner (Barker Ultrasonic Equipment Co., Ltd.).

[0042] Reference substances gallic acid (lot number 110831-201204, calculated by 89.90%), chlorogenic acid (lot number 110753-201314, calculated by 96.6%), 4-coumaric acid (lot number 112037-201801, calculated by 99.3%), paeonol Phenol (batch number 110708-201407, calculated as 99.90%) and α-cyperone (batch number 110748-201815, calculated as 99.7%) were purchased from China National Institutes for Food and Drug Control; new chlorogenic acid (batch number 130113001, ≥98%) , 1,2,3,4,6-pentagalloylglucose (batch number 17060201, calculated by 98.50%), and benzoyl paeoniflorin (batch number 17061803, calculated by 99.28%) were purchased from Che...

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Abstract

The invention provides a method for detecting a fingerprint spectrum of a medicinal preparation, which is used for simultaneously detecting various traditional Chinese medicine index components such as gallic acid, neochlorogenic acid, chlorogenic acid, 1, 2, 3, 4, 6-pentagalloylglucose, 4c-oumaric acid, benzoylpaeoniflorin, paeonol, curcuma zedoary furandienone, [alpha]-cyperus rotundus ketone and the like. The internal quality of the medicinal preparation is effectively controlled, and the safety and effectiveness of clinical medication of the medicine are further ensured.

Description

technical field [0001] The invention relates to the field of analysis and detection of pharmaceutical components, in particular to a detection method of a fingerprint of a pharmaceutical preparation. Background technique [0002] The pharmaceutical preparation described in the present invention is Gongliuxiao Capsule, which is a traditional Chinese medicine variety exclusively produced by Shandong Buchang Shenzhou Pharmaceutical Co., Ltd. Hedyotis diffusa, Cortex Moutan, and Cortex Evodia are composed of eleven medicinal materials, among which the four herbs of Rhizoma Cyperi (manufactured), Sanleng, Curcuma and Moutan Cortex are used as whole powder, and the rest of the herbs are used as medicine after being decocted and mellowed. This product has the effects of promoting blood circulation and removing blood stasis, softening hard masses and resolving stagnation. For uterine fibroids, which belongs to Qi stagnation and blood stasis syndrome. Symptoms: heavy menstrual flow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 王益民晁现民林永强于风蕊许丽丽崔巧红李军
Owner SHANDONG BUCHANG SHENZHOU PHARMA
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