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Cinnamon oil microsphere inclusion compound and preparation method and use thereof

A technology of cinnamon oil and clathrate, applied in the field of medicine, can solve the problems of slow release, limited wide use, easy oxidation, etc., and achieve the effect of improving stability, blood concentration and analgesic drug effect

Inactive Publication Date: 2021-02-02
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because cinnamon oil has disadvantages such as poor water solubility, easy oxidation, and easy volatility, it greatly limits its wide use in pharmaceutical preparations and food industries.
In order to increase the stability of volatile oils, methods such as cyclodextrin inclusion inclusion, porous material adsorption, and microcapsule coating are often used for inclusion and curing. However, these methods have complex inclusion processes, large amounts of excipients, and some components in vivo Slow release, poor stability, insoluble in water, etc.

Method used

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  • Cinnamon oil microsphere inclusion compound and preparation method and use thereof
  • Cinnamon oil microsphere inclusion compound and preparation method and use thereof
  • Cinnamon oil microsphere inclusion compound and preparation method and use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032]A cinnamon oil microsphere inclusion compound, which is characterized in that it is composed of the following parts by weight: cinnamon oil, povidone and Soluplus (polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer ), where the ratio of cinnamon oil, povidone and Soluplus is 2:14:0.5.

[0033]The preparation method is as follows: Weigh cinnamon oil, povidone and Soluplus according to the above mass ratio, add copovidone and Soluplus to an appropriate amount of ultrapure water to make the concentration of the solution 0.08g / mL, and stir in a 70℃ water bath for 2.5 h, spray drying (inlet air temperature 160°C, outlet air temperature 80°C, peristaltic pump speed 400mL / h) to prepare blank microspheres. Spray cinnamon oil into the blank microspheres, stir while spraying in, seal, and place in the dark for 12 hours to obtain the microsphere inclusion compound.

Embodiment 2

[0035]A cinnamon oil microsphere inclusion compound is characterized in that it is composed of the following components by weight: cinnamon oil, povidone and Soluplus, wherein the ratio of cinnamon oil, povidone and Soluplus is 3:10:1.5.

[0036]The preparation method is as follows: Weigh cinnamon oil, povidone and Soluplus according to the above mass ratio, add copovidone and Soluplus to a certain amount of ultrapure water to make the concentration of the solution 0.08g / mL, and stir in a 70℃ water bath. 2.5h, spray drying (inlet air temperature 160°C, outlet air temperature 80°C, peristaltic pump speed 400mL / h) to prepare blank microspheres. Spray cinnamon oil into the blank microspheres, stir while spraying in, seal, and place in the dark for 12 hours to obtain the microsphere inclusion compound.

Embodiment 3

[0038]A cinnamon oil microsphere inclusion compound is characterized in that it is composed of the following components by weight: cinnamon oil, povidone and Soluplus, wherein the ratio of cinnamon oil, povidone and Soluplus is 1.625:12:1.

[0039]The preparation method is as follows: Weigh cinnamon oil, povidone and Soluplus according to the above mass ratio, add copovidone and Soluplus to a certain amount of ultrapure water to make the concentration of the solution 0.08g / mL, and stir in a 70℃ water bath. 2.5h, spray drying (inlet air temperature 160°C, outlet air temperature 80°C, peristaltic pump speed 400mL / h) to prepare blank microspheres. Spray cinnamon oil into the blank microspheres, stir while spraying, seal, and place overnight in the dark to obtain the microsphere inclusion compound.

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Abstract

The present invention discloses a cinnamon oil microsphere inclusion compound. The cinnamon oil microsphere inclusion compound is composed of the following components in parts by weight: cinnamon oil,copovidone and Soluplus (a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) in a ratio of (1-3):(10-14):(0.5-1.5). After the cinnamon oil is included by copovidone-Soluplus spray-dried microspheres, stability of the cinnamon oil is enhanced, an in-vitro drug release, bioavailability and an analgesic effect of the cinnamon oil microsphere inclusion compound are basically kept consistent with those of the cinnamon oil and superior to those of a beta-cyclodextrin inclusion compound. Besides, the copovidone-Soluplus microsphere inclusion compound has relatively goodwater solubility. The preparation technology of the water-soluble blank microspheres is feasible. An encapsulation technology of the cinnamon oil is simple and has high encapsulation efficiency. Thepreferable technology has good technology repeatability and lays a foundation for solidifying the cinnamon oil.

Description

Technical field[0001]The invention relates to the technical field of medicine, in particular to a cinnamon oil microsphere inclusion compound and a preparation method and application thereof.Background technique[0002]Cinnamon oil is a yellow or yellow-brown volatile oil extracted from dried cinnamon bark. It has a variety of pharmacological effects such as antipyretic, analgesic, antibacterial, and antifungal. The main active ingredient is cinnamaldehyde. Because cinnamon oil has the disadvantages of poor water solubility, easy oxidation, and easy volatility, it greatly limits its wide use in pharmaceutical preparations and food industries. In order to increase the stability of volatile oil, methods such as cyclodextrin inclusion, porous material adsorption and microcapsule coating are often used for inclusion and curing. However, these methods have complex inclusion processes, large amounts of auxiliary materials, and some components in the body. Slow release, poor stability, and w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61K47/69A61K9/50A61K47/32A61K47/34A61P29/00A61K129/00
CPCA61K9/5026A61K9/5031A61K9/5089A61K36/54A61K47/6949A61P29/00
Inventor 鞠建明张振海张焕焕王云
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE