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Application of metabolic marker in atherosclerotic cerebral infarction

A technology of atherosclerosis and metabolites, applied in the field of biomedicine to achieve the effect of improving the quality of life

Active Publication Date: 2021-02-02
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In current clinical practice, the diagnosis of stroke mainly depends on clinicians' judgment of symptoms and signs and imaging examinations. However, many diseases such as migraine and epileptic seizures may have similar clinical manifestations to stroke, and imaging examinations also have certain limitations
In the past few decades, clinicians and scientists have been committed to finding biomarkers that can assist in the early diagnosis of cerebral infarction, although there is no one or several biomarkers with clear guiding significance that can be used for cerebral infarction auxiliary diagnosis, but with the continuous advancement of science and technology, more and more disease-related diagnostic biomarkers have been discovered

Method used

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  • Application of metabolic marker in atherosclerotic cerebral infarction
  • Application of metabolic marker in atherosclerotic cerebral infarction
  • Application of metabolic marker in atherosclerotic cerebral infarction

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Experimental program
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Embodiment

[0038] Example Screening and efficacy judgment of metabolites related to atherosclerotic cerebral infarction

[0039] 1. Sample collection

[0040] Blood samples were collected from 21 patients with atherosclerotic cerebral infarction and 21 patients with atherosclerosis.

[0041] Atherosclerotic cerebral infarction group inclusion criteria:

[0042] 1) The subjects have signed the informed consent

[0043] 2) Meet the diagnostic criteria for acute cerebral infarction in the "Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke in China (2014 Edition)".

[0044] 3) The etiological type is atherosclerotic cerebral infarction.

[0045] 4) Age 18-65 years old.

[0046] 5) BMI 18.5-23.9kg / m 2 .

[0047] 6) Blood routine: red blood cell count, MCHC, hemoglobin, white blood cell count, lymphocyte count, neutrophil count, and monocyte count were within the normal range.

[0048] 7) TG, TC, HDL-C, LDL-C, blood sugar, glycosylated hemoglobin are within the normal ...

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Abstract

The invention discloses an application of a metabolic marker in atherosclerotic cerebral infarction, which comprises the following steps: collecting blood samples of atherosclerotic cerebral infarction and atherosclerotic patients, carrying out metabonomics analysis, and discovering metabolites with significant differences in two groups, therefore, the metabolite is utilized to predict early atherosclerotic cerebral infarction, and early treatment of a patient is further realized.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the application of metabolic markers in atherosclerotic cerebral infarction. Background technique [0002] With the rapid development of the economy and the improvement of people's living standards, cerebrovascular disease has become a major disease that endangers human health and life. According to the population monitoring data provided by the Statistics Center of the Ministry of Health, nationwide, the ranking of cerebrovascular diseases in the ranking of all causes of death in recent years has shown a large upward trend, and cerebrovascular diseases have formed a population with cardiovascular diseases and malignant tumors. The three leading causes of death. [0003] Ischemic cerebral stroke (ICS), also known as cerebral infarction, ranks first in the incidence of cerebrovascular diseases, accounting for about 60% to 80%. Among them, large artery atherosclerotic stroke (LAA) is the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90G01N30/88G01N24/08G01N21/41G01N21/33G01N21/3577G01N21/359G01N27/327G01N23/00G01N27/62G01N27/64G01N30/72
CPCG01N21/33G01N21/3577G01N21/359G01N21/41G01N23/00G01N24/082G01N27/327G01N27/62G01N27/628G01N27/64G01N30/02G01N30/72G01N30/88G01N30/90G01N2030/8822
Inventor 张祥建张培培
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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