Immunochromatographic test strip for quantitatively detecting procalcitonin and quantitative detection method thereof

An immunochromatographic test strip, procalcitonin technology, applied in biological testing, measuring devices, analytical materials, etc., can solve problems such as low detection sensitivity, and achieve the effects of simple operation, improved linear range and stability, and rapid detection.
CN112305230AInactive Publication Date: 2021-02-02GUILIN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUILIN UNIVERSITY OF TECHNOLOGY
Publication Date
2021-02-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an immunochromatographic test strip for quantitatively detecting procalcitonin and a quantitative detection method thereof. The test strip comprises a PVC lining plate, a nitrocellulose membrane (NC membrane), a combination pad, a sample pad and a water absorption pad; the PVC lining plate is sequentially overlapped and pasted with the sample pad, the combination pad, the NC membrane and the water absorption pad from left to right; the binding pad contains a nanogold labeled first antibody for resisting procalcitonin; the nitrocellulose membrane is provided with a detection area and a control area, fluorescent strips are respectively arranged in the detection area and the control area, a detection line is arranged on the fluorescent strip of the detection area, an anti-procalcitonin coated antibody is used as the detection line, a control line is arranged on the fluorescent strip of the control area, and a procalcitonin antigen is coated on the control line. Compared with a common method for detecting procalcitonin at present, the method has the advantages of simplicity and convenience in operation, quickness, convenience in carrying, small sample consumption and the like, and meanwhile, the linear range and the stability of detection are also improved.
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Description

technical field

[0001] The invention relates to procalcitonin detection technology, belongs to the field of immunochemical detection, in particular to an immunochromatographic test strip for quantitative detection of procalcitonin and a quantitative detection method thereof. Background technique

[0002] Procalcitonin (PCT) is a glycoprotein synthesized in thyroid C cells. It is one of the biomarkers that reflect the systemic inflammation of the organism. It is a pro-peptide substance of calcitonin without calcitonin hormone activity. , The structure of PCT is composed of 116 amino acids. When the tissues and organs in the organism face the invasion of bacteria, fungi and other endotoxins and inflammatory factors, almost all PCT can be synthesized.

[0003] When a bacterial infection occurs in the human body, the content of PCT in plasma can rise sharply in a short period of time and maintain a high level within 24 hours. When diseases such as aseptic inflammation and viral ...

Claims

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