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A kind of preparation method of meso-2,3-butanediol

A technology of butanediol and meso, which is applied in the field of preparation of meso-2,3-butanediol, can solve the problems of skin toxicity, skin irritation, allergy and low skin irritation

Active Publication Date: 2021-04-06
SUZHOU SUZHEN BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Meso-2,3-butanediol (Meso-2,3-butanediol) is one of the stereoisomers of 2,3-butanediol. Studies have shown that meso-2,3-butanediol -butanediol compared to other stereoisomers of 2,3-butanediol (L-form (L-(+)-2,3-butanediol), D-form (D-(-)-2,3 -butanediol)), has higher antibacterial ability and antiseptic ability, and is less irritating to the skin, such as patent CN2015800553290; and in fact, even currently known such as parabens, imidazolidine Preservatives such as urea, phenoxyethanol or chlorphenesin, although they can suppress and eliminate microorganisms in the composition and improve the preservability of the product, they all cause skin irritation and allergies, and in severe cases can also cause Skin toxicity; it can be seen that compared with known antibacterial and antiseptic products, meso-2,3-butanediol has excellent application value in antibacterial, antiseptic and daily chemical products, etc.
However, the efficient preparation of meso-2,3-butanediol has not been reported yet

Method used

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  • A kind of preparation method of meso-2,3-butanediol
  • A kind of preparation method of meso-2,3-butanediol
  • A kind of preparation method of meso-2,3-butanediol

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preparation example Construction

[0033] Based on the above findings, the present invention provides a method for preparing meso-2,3-butanediol, the preparation method comprising the following steps:

[0034] (1) Using renewable biomass as raw material, Klebsiella is used to ferment 2,3-butanediol to obtain 2,3-butanediol fermentation broth;

[0035] (2) The 2,3-butanediol fermentation broth obtained in step (1) is sequentially subjected to ultrafiltration for sterilization and protein removal, nanofiltration for protein and partial salt removal, electrodialysis for desalination, and Multi-effect evaporation to remove part of the water to obtain a concentrated solution;

[0036] (3) dehydrating the concentrated solution obtained in step (2) using the first rectification tower to obtain a dehydration liquid, and then distilling the dehydration liquid to obtain a distillate;

[0037] (4) The distillate obtained in step (3) is rectified in the second rectification tower, and 3-hydroxy-2-butanone is separated fro...

Embodiment 1

[0057] This example provides a preparation method of meso-2,3-butanediol, the preparation method comprising the following steps:

[0058] (1) Using renewable biomass (specifically glycerol) as raw material, Klebsiella is used to ferment 2,3-butanediol to obtain 2,3-butanediol fermentation liquid; the specific implementation method is as follows:

[0059] After inoculation in the fermenter, control the temperature of the fermentation broth to 37°C, pH value to 6.5, ventilation rate to 0.08vvm, stirring rate to 50rpm, measure the concentration of substrate glycerol in the fermentation broth during the fermentation process, and add glycerol according to the consumption rate of glycerol to ensure that the glycerol in the fermentation broth The concentration is 0.5-30g / L, fermented for 48 hours and put into the tank;

[0060] (2) The 2,3-butanediol fermentation liquid obtained in step (1) is sequentially carried out:

[0061] It is used for ultrafiltration for sterilization and pr...

Embodiment 2

[0077] This example provides a preparation method of meso-2,3-butanediol, the preparation method comprising the following steps:

[0078] (1) Using renewable biomass (specifically glycerol) as raw material, Klebsiella is used to ferment 2,3-butanediol to obtain 2,3-butanediol fermentation liquid; the specific implementation method is as follows:

[0079] After inoculation in the fermenter, control the temperature of the fermentation broth to 37°C, pH value to 6.5, ventilation rate to 0.08vvm, stirring rate to 50rpm, measure the concentration of substrate glycerol in the fermentation broth during the fermentation process, and add glycerol according to the consumption rate of glycerol to ensure that the glycerol in the fermentation broth The concentration is 0.5-30g / L, fermented for 48 hours and put into the tank;

[0080] (2) The 2,3-butanediol fermentation liquid obtained in step (1) is sequentially carried out:

[0081] It is used for ultrafiltration for sterilization and pr...

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Abstract

The invention discloses a preparation method of meso-2,3-butanediol, which comprises the following steps: using renewable biomass as a raw material, adopting Klebsiella to ferment and produce 2,3-butanediol, Obtain 2,3-butanediol fermentation liquid, then carry out ultrafiltration, nanofiltration, electrodialysis, multi-effect evaporation successively, then use the first rectification tower to carry out dehydration, distillation, rectification in the second rectification tower, and 3-hydroxy-2-butanone is separated from the top of the tower, and 2,3-butanediol is extracted from the side line; the 2,3-butanediol extracted from the side line is rectified in the third rectification tower, and the side line is extracted Meso-2,3-butanediol is produced by activated carbon adsorption of meso-2,3-butanediol extracted from the side line; the purity of meso-2,3-butanediol prepared by this method It can reach more than 90%, chroma ≤ 10 black, no peculiar smell, and then make full use of its excellent antibacterial and antiseptic capabilities, and has no irritation to the skin, etc., meeting the quality requirements of daily chemical and polymer grade products.

Description

technical field [0001] The invention belongs to the technical field of preparation of 2,3-butanediol and stereoisomers thereof, and in particular relates to a preparation method of meso-2,3-butanediol. Background technique [0002] Meso-2,3-butanediol (Meso-2,3-butanediol) is one of the stereoisomers of 2,3-butanediol. Studies have shown that meso-2,3-butanediol -butanediol compared to other stereoisomers of 2,3-butanediol (L-form (L-(+)-2,3-butanediol), D-form (D-(-)-2,3 -butanediol)), has higher antibacterial ability and antiseptic ability, and is less irritating to the skin, such as patent CN2015800553290; and in fact, even currently known such as parabens, imidazolidine Preservatives such as urea, phenoxyethanol or chlorphenesin, although they can suppress and eliminate microorganisms in the composition and improve the preservability of the product, they all cause skin irritation and allergies, and in severe cases can also cause Skin toxicity; it can be seen that compa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C29/74C07C29/76C07C29/80C07C31/20C12P7/18C12R1/22
CPCC07C29/74C07C29/76C07C29/80C12P7/18C07C31/207
Inventor 罗吉安张叶兴张赟石国柱刘宾酆华
Owner SUZHOU SUZHEN BIOLOGICAL ENG CO LTD