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A lipid droplet targeting fluorescent probe and its synthesis method and application

A technology of a fluorescent probe and a synthesis method, which is applied in the field of lipid droplet-targeted fluorescent probes and their synthesis, and achieves the effects of improving sensitivity and signal-to-noise ratio, readily available raw materials, and simple operation.

Active Publication Date: 2022-06-03
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although a large number of fluorescent probes have been reported, the fluorescent probes for lipid droplet-specific imaging still need to be further developed, especially lipid droplet targets that have no fluorescence at all in aqueous or organic solvents but have strong fluorescent signals in lipid droplets. Directional fluorescent probes urgently need to be developed

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  • A lipid droplet targeting fluorescent probe and its synthesis method and application
  • A lipid droplet targeting fluorescent probe and its synthesis method and application
  • A lipid droplet targeting fluorescent probe and its synthesis method and application

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Embodiment 1

[0039]

Embodiment 2

[0043]

Embodiment 3

[0047]

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Abstract

The invention discloses a lipid droplet targeting fluorescent probe and its synthesis method and application. The synthesis method comprises the following steps: triphenylamine phenylboronic acid compound and 4-chloro-7-nitrobenzo-2-oxa-1 ,3-Oxadiazole is reacted in an organic solvent at 60-120°C for 10-50 hours under the protection of an inert gas and under the action of a catalyst and a base, cooled to room temperature, then added dichloromethane, filtered, and the solvent is removed under reduced pressure, separated and purified The product, dried, can be. The fluorescent probe of the present invention has no fluorescence in aqueous solution and basically no fluorescence in organic solvent, but has strong fluorescence in oil and can specifically target lipid droplets in cells.

Description

A kind of lipid droplet targeting fluorescent probe and its synthesis method and application technical field The invention belongs to the technical field of biomedicine, in particular to a kind of lipid droplet targeting fluorescent probe and its synthetic method and application. Background technique [0002] Lipid droplets are the main storage sites for intracellular lipids and are important energy storage centers for cells. Not only that, but also the lipid droplets A complex, dynamically changing multifunctional organelle that functions in intracellular lipid metabolism and storage, protein degradation, signaling and It plays a very important role in membrane transport and other processes. And the development of various diseases is also closely related to lipid droplets, such as atherosclerosis. such as cirrhosis, fatty liver and obesity. The content of lipid droplets in various types of cells and the dynamic change process of lipid droplets are important for stu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D271/12C09K11/06G01N21/64
CPCC07D271/12C09K11/06G01N21/6428G01N21/6458C09K2211/1014C09K2211/1048G01N2021/6439Y02P20/55
Inventor 李淑芬
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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