Preparation method and product of ceramide and fat-soluble active matter skin co-permeation carrier

A ceramide, fat-soluble technology, applied in skin care preparations, medical preparations containing active ingredients, cosmetic preparations, etc., to achieve the effect of loose accumulation structure, promote transdermal delivery, and promote skin hydration

Active Publication Date: 2021-02-09
RAYTING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN106691889A discloses a preparation method and application of a high skin retention ceramide nanocomposition. Although the patent examines the transdermal condition of ceramide after being carried, it does not further combine ceramide with other fat-soluble active substances Together, to construct a

Method used

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  • Preparation method and product of ceramide and fat-soluble active matter skin co-permeation carrier
  • Preparation method and product of ceramide and fat-soluble active matter skin co-permeation carrier
  • Preparation method and product of ceramide and fat-soluble active matter skin co-permeation carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Caprylic capric triglyceride: 5g

[0037] Octyldodecanol: 1.5g

[0038] Cetearyl Alcohol: 0.5g

[0039] Ceramide 3: 2g

[0040] Cholesterol: 0.7g

[0041] Palmitic acid: 0.7g

[0042] Hydrogenated Lecithin: 5g

[0043] Glycerin: 60g

[0044] Water: balance, add water to make up to 100g

[0045] Mix glycerin with water, and stir magnetically in a water bath at 85°C until the water phase is clear and transparent;

[0046] Heat and dissolve ceramide 2, cholesterol, and palmitic acid in a water bath at 85°C, and mix with caprylic capric triglyceride, octyldodecanol, cetearyl alcohol, and hydrogenated lecithin until the oil phase is clear transparent;

[0047] Add the water phase to the oil phase, use high-speed dispersion and 15000rpm, disperse for 3 minutes, then homogenize under high pressure at 90Mpa, cycle 5 times, and cool at room temperature to obtain the ceramide carrier.

[0048] The obtained carrier is a translucent liquid, the loading capacity of ceramide i...

Embodiment 2

[0052] Stearyl alcohol: 1.5g

[0053] Octyldodecanol: 0.5g

[0054] Caprylic capric triglyceride: 5g

[0055] Coenzyme Q10: 7g

[0056] Hydrogenated Lecithin: 4g

[0057] Glycerin: 75g

[0058] Water: balance, add water to make up to 100g

[0059] Mix glycerin with water, and stir magnetically in a water bath at 85°C until the water phase is clear and transparent; mix the solubles of coenzyme Q10, caprylic capric triglyceride, octyldodecanol, cetearyl alcohol and hydrogenated lecithin, Until the oil phase is transparent; add the water phase to the oil phase, use high-speed dispersion and 15000rpm, disperse for 3min, then homogenize under high pressure at 90Mpa, cycle 5 times, and cool at room temperature to obtain the carrier for carrying coenzyme Q10.

[0060] The obtained carrier is a translucent liquid, the loading capacity of coenzyme Q10 is 7%, and the encapsulation efficiency is about 98.5%. The particle size is 77nm measured by Zeta potential and nano particle size...

Embodiment 3

[0062] Stearyl alcohol: 1.5g

[0063] Octyldodecanol: 0.5g

[0064] Caprylic capric triglyceride: 5g

[0065] Coenzyme Q10: 7g

[0066] Ceramide 3: 0.5g

[0067] Cholesterol: 0.2g

[0068] Palmitic acid: 0.2g

[0069] Hydrogenated Lecithin: 4g

[0070] Glycerin: 75g

[0071] Water: balance, add water to make up to 100g

[0072] Mix glycerin and water, and stir magnetically in a water bath at 85°C until the water phase is clear and transparent; heat and dissolve ceramide 3, cholesterol, and palmitic acid in a water bath at 85°C, and mix with coenzyme Q10, caprylic capric triglyceride, Mix octyldodecanol, stearyl alcohol and hydrogenated lecithin solubilized until the oil phase is clear and transparent; add the water phase to the oil phase, use high-speed dispersion and 15000rpm, disperse for 3min, then homogenize under high pressure at 90Mpa, cycle 5 times, Cool at room temperature to obtain a carrier carrying ceramide and coenzyme Q10.

[0073] The obtained carrier is...

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Abstract

The invention discloses a preparation method and product of a ceramide and fat-soluble active matter skin co-permeation carrier, and the ceramide and fat-soluble active matter skin co-permeation carrier comprises ceramide, fat-soluble active matter, phospholipid, cholesterol, fatty acid, phytosphingosine, liquid lipid, solid lipid, polyhydric alcohol and water. The carrier is positively charged; aternary permeation-promoting system can significantly improve the permeation amount of the ceramide in the cuticle of the skin, and the effects of the ceramide to enhance skin hydration and improve lipid fluidity of the cuticle are exerted, and thus, skin permeation of the fat-soluble active matter in the carrier is promoted, and the purpose of co-permeation is achieved.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a preparation method and a product of a skin co-penetration carrier of ceramide and fat-soluble active substances. Background technique [0002] Ceramides are a class of substances formed by the covalent combination of sphingosines with different degrees of saturation or different numbers of hydroxyl groups and fatty acids with different carbon chain lengths or degrees of saturation. Ceramide accounts for about 40% to 50% of the lipids in the stratum corneum of the skin. It is an important class of lipids to maintain the normal physiological functions of the skin. It can repair damaged skin and promote the renewal of the natural protective layer of the skin. As a natural moisturizing factor, ceramide has a strong ability to associate with water molecules. After it is applied to the skin, it can promote skin hydration and has excellent moisturizing effect. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/31A61K8/34A61K8/35A61K8/36A61K8/37A61K8/41A61K8/49A61K8/55A61K8/67A61K8/68A61Q19/00
CPCA61K8/31A61K8/34A61K8/345A61K8/347A61K8/35A61K8/355A61K8/361A61K8/375A61K8/41A61K8/498A61K8/553A61K8/671A61K8/678A61K8/68A61K8/922A61K2800/10A61Q19/00
Inventor 梁蓉杨成王玙璇
Owner RAYTING BIOTECHNOLOGY CO LTD
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