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Application of β3-adrenergic receptor agonist in preparation of medicine for treating nervous system diseases

A technology of epinephrine and nervous system inflammation, applied in the field of medicine, can solve problems such as unclear, and achieve the effect of reducing tissue damage

Active Publication Date: 2022-02-22
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The proliferation and differentiation of bone marrow-derived immune cells are jointly regulated by external environmental factors and internal signaling pathways. However, the dynamic regulation of hematopoietic stem cells in neuroinflammatory diseases and its impact on the development and prognosis of neuroimmune inflammatory diseases, not yet clear

Method used

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  • Application of β3-adrenergic receptor agonist in preparation of medicine for treating nervous system diseases
  • Application of β3-adrenergic receptor agonist in preparation of medicine for treating nervous system diseases
  • Application of β3-adrenergic receptor agonist in preparation of medicine for treating nervous system diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: Clinical symptoms and cell differentiation and cell infiltration detection of EAE model mice

[0074] 1. Experimental animals:

[0075] C57 / BL6 mice, 12 weeks old, female, were randomly divided into mirabegron administration group and control group;

[0076] Fgd5-creER-tdTomato mice, 12 weeks old, female, were randomly divided into mirabegron administration group and control group.

[0077] 2. Model establishment:

[0078] The mouse polypeptide antigen MOG35-55 (M-E-V-G-W-Y-R-S-P-F-S-R-V-V-H-L-Y-R-N-G-K, purity > 95%) and complete Freund's adjuvant containing inactivated Mycobacterium tuberculosis were repeatedly mixed and emulsified in a syringe to form a water-in-oil state. The skin on the back of both lower limbs of the mouse was selected as the injection point, and the emulsion (200 μg of MOG35-55, 500 μg of inactivated Mycobacterium tuberculosis) was injected subcutaneously, 100 μl on each side, and a total of 200 μl was injected. Pertussis toxin 200n...

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PUM

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Abstract

The invention belongs to the technical field of medicine, and relates to the application of a β3-adrenoceptor agonist in the preparation of medicines for treating or preventing nervous system diseases. The present invention finds through research that the β3-adrenergic receptor agonist can inhibit the differentiation of bone marrow hematopoietic stem cells and related precursor cells in the mouse model of autoimmune encephalomyelitis (EAE), reduce neutrophils and CD4 + Generation of T lymphocytes, B lymphocytes, etc., thereby reducing CD4 + The infiltration of T lymphocytes and B lymphocytes into the central nervous system can finally inhibit the central nervous system inflammation of EAE mice and reduce tissue damage, which has important clinical application value for the treatment of neuroinflammatory diseases and immune diseases. The invention also discloses a pharmaceutical composition, which includes a β3-adrenergic receptor agonist and can be used as a therapeutic drug for nervous system diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of β3-adrenergic receptor agonists in the preparation of medicines for treating or preventing nervous system diseases, in particular to the application of Mirabegron in the preparation of medicines for treating or preventing nervous system diseases . Background technique [0002] Inflammation is a moderate or abnormal systemic response of the body's immune system based on changes in the internal and external environment. Moderate inflammatory immune responses play an important role in protecting the body from pathological damage to the internal environment, but excessive inflammation and immune responses can cause central nervous system System (Central Nervous System, CNS) and peripheral nervous system (Peripheral Nervous System, PNS) damage, leading to nervous system inflammatory diseases. In recent years, it has been found that secondary inflammation and immune ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/426A61P25/00A61P29/00A61P37/06
CPCA61K45/00A61K31/426A61P25/00A61P29/00A61P37/06
Inventor 刘强史凯斌施福东孔颍
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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