Immunocompatible reversible universal pluripotent stem cells and application thereof

A kind of pluripotent stem cell and general-purpose technology, which is applied in immunocompatibility and reversible general-purpose pluripotent stem cell and its application field, can solve the problems of high risk of disease, no better solution to the problem, shrinking of antigen integrity and other problems, and achieve functional The effect of both sex and safety
CN112342196APending Publication Date: 2021-02-09FUTURE HOMO SAPIENS INST OF REGENERATIVE MEDICINE CO LTD (FHSR) +1
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
FUTURE HOMO SAPIENS INST OF REGENERATIVE MEDICINE CO LTD (FHSR)
Publication Date
2021-02-09

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Abstract

The invention discloses immunocompatible reversible universal pluripotent stem cells or derivatives thereof. An inducible gene expression system and an expression sequence of at least one immunocompatible molecule are introduced into the genome of the pluripotent stem cells or the derivatives thereof. The immunocompatible molecules are used for regulating and controlling the expression of genes related to immune response in pluripotent stem cells or derivatives of the pluripotent stem cells. The expression of the immunocompatible molecule is regulated and controlled by an inducible gene expression system. According to the technical scheme, the immunocompatibility between the graft and the receptor can be improved, and the antigen presentation capability of graft cells can be reversibly recovered, so that the clinical safety of such universal pluripotent stem cells and derivatives is improved, and the clinical application value of the universal pluripotent stem cells and derivatives isgreatly expanded.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering, and in particular relates to an immune-compatible and reversible universal pluripotent stem cell and its application. Background technique

[0002] Stem cells are a type of "seed" cells with the ability to self-renew and differentiate into specific functional somatic cells. They have the potential to regenerate into various tissues and organs and the human body, and play an important role in major biological activities such as immune response, aging, and tumorigenesis. core and irreplaceable role. According to the degree of stem cell characteristics, stem cells are mainly divided into: totipotent stem cells (Totipotent stem cells), pluripotent stem cells (Pluripotent stem cells, PSCs) and adult stem cells (adult stem cells).

[0003] Among them, pluripotent stem cells (PSCs) have almost unlimited self-renewal ability and the potential to develop and differentiate into organs, tissues...

Claims

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