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Traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and preparation method thereof

A skin reaction and traditional Chinese medicine technology, applied in skin diseases, medical formulas, medical preparations with non-active ingredients, etc., can solve the problems of complex use methods, obvious pain, and aggravated pain, so as to achieve simple use methods and patient compliance Good, less toxic and side effects

Inactive Publication Date: 2021-02-19
THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When using traditional Chinese medicine for external washing, it needs to be soaked for a long time and applied externally. Oral Chinese medicine decoction needs to be boiled in advance. The method of use is more complicated and time-consuming
Patients with grade 2-3 hand-foot skin adverse reactions have obvious pain, accompanied by different degrees of chapping and ulceration, which may aggravate the pain during external washing and external application
[0007] Based on the above status quo, traditional Chinese medicine has considerable curative effect in the treatment of TKIs-induced hand-foot skin reaction. However, there are various prescriptions, complicated methods of use, and many adverse reactions. There is still great resistance to further promotion.

Method used

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  • Traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and preparation method thereof
  • Traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and preparation method thereof
  • Traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0034] Liang, female, 64 years old. In July 2019, a high-grade ovarian serous carcinoma with multiple abdominal and pelvic metastases was detected. After multiple courses of neoadjuvant chemotherapy, the "Ovarian Cancer Tumor Reduction Surgery" was successfully performed on October 25, 2019, and a total of 8 courses were completed after the operation. After adjuvant chemotherapy, the regimen was changed to "apatinib 0.25g qd+cyclophosphamide 50mg tid d1-10" for maintenance. After 1 cycle, the patient experienced swelling and pain in the fingers of both hands, followed by molting, erythema, such as figure 1 As shown in the middle left picture, it is considered to be a grade 3 hand-foot skin adverse reaction. After cleaning the hands, apply this product externally, and wear film gloves to strengthen moisturizing. After 2 days of application, the pain in the patient's hands is significantly less than before, and continue to use this product until 5 days later , finger rash basic...

Embodiment 2

[0036] Yang, female, 27 years old, underwent palliative resection for "hepatocellular carcinoma" on August 16, 2019, and her condition was not well controlled after the operation. Since May 2020, she has been using "regorafenib" targeted therapy, taking After 2 cycles, multiple blisters appeared on the palms of both toes of the patient, and gradually ruptured, accompanied by obvious pain, such as figure 2 As shown in the left picture in the middle, it is considered to be a grade 3 hand-foot skin adverse reaction. After cleaning the feet, apply this product externally on the affected area, and wear a film foot cover to strengthen moisturizing. After applying the drug, the patient's pain gradually relieved. The blisters on both feet are basically healed, such as figure 2 Shown in the figure on the right.

[0037] In addition, there are many patients who use the present invention to prevent and treat TKIs that cause hand-foot skin reactions. A total of 25 cases using the prese...

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Abstract

The invention discloses a traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and a preparation method thereof. The traditional Chinese medicine compoundointment comprises 25-35 parts of geranium wilfordii, 25-35 parts of radix sophorae flavescentis, 25-35 parts of cortex dictamni, 25-35 parts of cortex lycii radicis, 25-35 parts of lithospermum, 25-35 parts of red peony roots, 100-120 parts of urea cream and 0.35-0.45 part of vitamin E. On the basis of syndrome differentiation and treatment, the traditional prescription is improved and simplified, the mild traditional Chinese medicines including geranium wilfordii, radix sophorae flavescentis, cortex dictamni, cortex lycii radicis, lithospermum and red peony roots are adopted, decoction is prepared through decoction, filtration and other methods, and the decoction is mixed with urea cream to prepare the traditional Chinese medicine compound ointment. Compared with a traditional scheme, the use method is simple and faster, toxic and side effects are small, patient compliance is better, and a positive curative effect is obtained in practical application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound ointment, in particular to a traditional Chinese medicine compound ointment for treating hand-foot skin reaction caused by TKIs and a preparation method thereof. Background technique [0002] Hand-foot skin reaction (HFSR) is a skin toxicity reaction caused by a variety of chemotherapy, targeted drugs and other anti-tumor drugs, and the incidence rate can be between 6-64%. The main manifestations are hypoesthesia, numbness and tingling in the hands and feet, redness and swelling of the skin, formation of blisters, desquamation, chapping and even ulceration. Recurrent attacks are often accompanied by skin infections, causing keratosis of the palms and toes, and disappearance of fingerprints. It belongs to drug-induced rash, which is different from common microbial infections, allergies, etc., and is closely related to the drugs used. The effect of ordinary methods is limited, and it is oft...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K47/06A61K47/22A61P17/00A61K9/06A61K31/155A61K31/355
CPCA61K9/06A61K31/155A61K31/355A61K36/185A61K36/30A61K36/489A61K36/65A61K36/71A61K36/75A61K36/815A61K47/06A61K47/22A61K2236/331A61K2236/39A61P17/00A61K2300/00
Inventor 张梅吴悦佘园园
Owner THE FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIV