Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of salicylic acid supramolecular preparation and preparation method thereof

A salicylic acid and supramolecular technology, which is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of prolonging the action time, heavy smear feeling, sticky skin feeling, etc., and achieve biological High utilization rate, good water dispersibility and low irritation effect

Active Publication Date: 2022-03-18
PROYA COSMETICS
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, salicylic acid has the following application problems: the solubility of salicylic acid in water at 20 °C is 2 g / L, and it is almost insoluble in water. It is easy to form crystals and precipitate when directly added to skin care formulas, reducing its bioavailability; To ensure the stability of the product and avoid the crystallization of salicylic acid, in practical applications, it is often necessary to use a large amount of alcohol to dissolve it first, and then add a large amount of surfactant to help it dissolve in water
Salicylic acid derivatives include betaine salicylate, octanoyl salicylate, tridecyl salicylate, etc. These substances have been chemically modified to improve their solubility or irritation to a certain extent. However, compared with salicylic acid, these salicylic acid derivatives are greatly reduced in efficacy
The Chinese invention patent "Preparation Method of Salicylic Acid Liposome and Its Series of External Preparations and Its Application in Acne Treatment" (ZL 201010146934.8) uses liposome as the drug delivery system to encapsulate salicylic acid, and then endow it with emulsion, External dosage forms such as gels and creams can reduce the irritation of salicylic acid to the skin, prolong the action time, and have good curative effect, but for water-based products, especially transparent system products, there are still problems that are not easy to apply. question
Chinese invention patent "a composite wall material microcapsule loaded with salicylic acid and its preparation method" (ZL201810022817.7) uses the inclusion complexation method to wrap β-cyclodextrin and carboxymethyl cellulose on the surface of salicylic acid The wall material compounded with sodium or ethyl cellulose finally obtains a composite wall material microcapsule loaded with salicylic acid, thereby improving the dispersibility of salicylic acid in water, but the capsule formed by it is relatively hard and has hard Grainy texture, affecting the applicability of cosmetics
Chinese invention patent "Water-Soluble Supramolecular Complex" (ZL 201580063447.6) uses a water-soluble block copolymer and at least one associated gel adjuvant to form a water-soluble supramolecular complex of salicylic acid and its derivatives, effectively solving the problem of The precipitation of salicylic acid is a problem, but the water-soluble supramolecular complex is a paste substance. When it is added to cosmetics, its immediate application feeling is very thick, and the skin feels sticky after application, which directly affects the pleasant use that cosmetics should have. sense

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of salicylic acid supramolecular preparation and preparation method thereof
  • A kind of salicylic acid supramolecular preparation and preparation method thereof
  • A kind of salicylic acid supramolecular preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: a kind of salicylic acid supramolecular preparation and preparation method thereof, is characterized in that, adopts the following steps:

[0057] A: Take by weight 50% salicylic acid, 20% polyquaternium-61, 15% polyol, 15% montmorillonite; said polyol is a kind of isohexanediol and isoprene glycol or their Mixtures in any ratio;

[0058] B: Weigh an appropriate amount of absolute ethanol, mix the salicylic acid weighed in step A with absolute ethanol at room temperature according to a mass ratio of 1:5, and stir until the salicylic acid is completely dissolved to obtain a salicylic acid ethanol solution;

[0059] C: Mix the polyquaternium-61 and the polyol weighed in step A at room temperature, and stir until the polyquaternium-61 is completely dispersed in the polyol to obtain a polyquaternium-61 polyol dispersion solution;

[0060] D: At 48 °C, mix the salicylic acid ethanol solution obtained in step B with the polyquaternium-61 polyol dispersion solut...

Embodiment 2

[0062] Embodiment 2: a kind of salicylic acid supramolecular preparation and preparation method thereof, is characterized in that, adopts the following steps:

[0063] A: Take by weight 15% salicylic acid, 25% polyquaternium-61, 35% polyol, 25% montmorillonite; said polyol is a kind of isohexanediol and isoprene glycol or their Mixtures in any ratio;

[0064] B: Weigh an appropriate amount of absolute ethanol, mix the salicylic acid weighed in step A with absolute ethanol at room temperature according to a mass ratio of 1:5, and stir until the salicylic acid is completely dissolved to obtain a salicylic acid ethanol solution;

[0065] C: Mix the polyquaternium-61 and the polyol weighed in step A at room temperature, and stir until the polyquaternium-61 is completely dispersed in the polyol to obtain a polyquaternium-61 polyol dispersion solution;

[0066] D: At 55 ° C, mix the salicylic acid ethanol solution obtained in step B with the polyquaternium-61 polyol dispersion solu...

Embodiment 3

[0068] Embodiment 3: a kind of salicylic acid supramolecular preparation and preparation method thereof, is characterized in that, adopts the following steps:

[0069] A: Take by weight 30% salicylic acid, 18% polyquaternium-61, 32% polyol, 20% montmorillonite; said polyol is a kind of isohexanediol and isoprene glycol or their Mixtures in any ratio;

[0070] B: Weigh an appropriate amount of absolute ethanol, mix the salicylic acid weighed in step A with absolute ethanol at room temperature according to a mass ratio of 1:5, and stir until the salicylic acid is completely dissolved to obtain a salicylic acid ethanol solution;

[0071] C: Mix the polyquaternium-61 and the polyol weighed in step A at room temperature, and stir until the polyquaternium-61 is completely dispersed in the polyol to obtain a polyquaternium-61 polyol dispersion solution;

[0072] D: At 62°C, mix the salicylic acid ethanol solution obtained in step B with the polyquaternium-61 polyol dispersion soluti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a salicylic acid supramolecular preparation and a preparation method thereof, which is characterized in that it consists of the following components in mass percentage: 15-50% salicylic acid, 18-25% polyquaternium-61, 15-35% % polyol, 15 ~ 25% montmorillonite; the polyol is a kind of isohexanediol and isoprene glycol or their mixture in any ratio. The obtained salicylic acid supramolecular preparation has the advantages of good water dispersibility, low irritation, high bioavailability, etc., and is convenient to be added to products such as medical dressings and cosmetics.

Description

technical field [0001] The invention relates to the technical field of cosmetic preparation, in particular to a salicylic acid supramolecular preparation and a preparation method thereof. Background technique [0002] Salicylic acid is a type of beta-hydroxy acid. Salicylic acid has functions such as keratin regulation, pore unclogging, pore shrinkage, oil control, and anti-inflammation, and is widely used in cosmetics. However, salicylic acid has the following application problems: the solubility of salicylic acid in water at 20 °C is 2 g / L, and it is almost insoluble in water. It is easy to form crystals and precipitate when directly added to skin care formulas, reducing its bioavailability; To ensure the stability of the product and avoid the crystallization of salicylic acid, in practical applications, it is often necessary to use a large amount of alcohol to dissolve it first, and then add a large amount of surfactant to help it dissolve in water. However, the high co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/26A61K8/34A61K8/368A61L15/18A61L15/20A61L15/44A61Q19/00
CPCA61K8/26A61K8/368A61K8/345A61K8/817A61Q19/00A61L15/20A61L15/18A61L15/44A61K2800/10C08L79/00
Inventor 黄洁芳蒋丽刚毕永贤王晗宁
Owner PROYA COSMETICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com