Focal adhesion kinase (FAK)-targeting compound and preparation method and application thereof

A technology of compound and precursor compound, applied in the field of compound, can solve the problem that tumor suppressor activity needs to be improved, and achieve the effect of good affinity, high selectivity and strong specificity
CN112390760AActive Publication Date: 2021-02-23BEIJING NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Publication Date
2021-02-23

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Abstract

An embodiment of the invention provides an FAK-targeting compound as well as a preparation method and application of the compound. The compound has a structure as shown in a general formula (I) whichis described in the specification. The compound provided by the invention has high affinity with FAK, and can be used as a compound for targeting FAK. Furthermore, since the FAK-targeting compound provided by the invention has an inhibition effect on FAK, the FAK-targeting compound can be used for preparing tumor treatment medicines; Besides, after the FAK-targeting compound provided by the invention is subjected to radiochemical labeling, the FAK-targeting compound can be used as a tumor diagnosis imaging agent for preparing tumor diagnosis drugs. The FAK-targeting compound provided by the invention has the characteristics of good affinity, strong specificity and high selectivity, and has clinical application value.
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Description

technical field

[0001] The invention relates to the technical field of compounds, in particular to a compound targeting FAK and its preparation method and application. Background technique

[0002] Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase, which is highly or overexpressed in most types of tumor cells, and plays an important role in the occurrence, development and metastasis of tumors. Links play a crucial role, especially in the process of tumor evolution to a malignant invasive phenotype. In theory, blocking the expression of FAK or inhibiting the function of FAK may achieve the purpose of inhibiting the invasion and metastasis of tumor cells. Therefore, FAK is a potential target for tumor diagnosis and treatment.

[0003] It is necessary to develop radiopharmaceuticals with high tumor specificity and high sensitivity. Over the past three decades, a number of radiopharmaceuticals have been designed and developed to image and identify the unique bioch...

Claims

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