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Method for extracting iridoid compounds from Patrinia scabiosaefolia

A technology of iridoids and patinate, applied in organic chemistry methods, organic chemistry, etc., to achieve good development and utilization, enrich the source of raw materials, and be conducive to sustainable utilization

Active Publication Date: 2021-02-23
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen that (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol has broad application prospects, yet, there is no extraction from Patrinia plants (4 β ,8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol report

Method used

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  • Method for extracting iridoid compounds from Patrinia scabiosaefolia
  • Method for extracting iridoid compounds from Patrinia scabiosaefolia

Examples

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Embodiment 1

[0025] A method for extracting iridoids from the whole plant of Patrinia chinensis, comprising the following steps:

[0026] 1) Use 9.1kg of dried Patrinia officinalis as raw material, crush it and extract it with 75% ethanol to obtain the extract (soak and extract at 50°C for 3 times, each time for 3 days, and combine the extract; The amount of 75% ethanol added is 25L), and the solvent is recovered under reduced pressure to obtain the extract; 60% ethanol, 80% ethanol and 95% ethanol gradient elution, collect 40% ethanol elution fraction;

[0027] 2) Mix the eluted part of 40% ethanol with 300~400 mesh silica gel according to the weight ratio of 1:30, then pack the sample into the column, elute with dichloromethane-methanol with a volume ratio of 20:1, detect it by thin layer chromatography, and combine the same groups Separate and recover the solvent under reduced pressure to obtain the crude product.

[0028] 3) The crude product obtained in step 2) was mixed with silica...

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Abstract

The invention discloses a method for extracting iridoid compounds from Patrinia scabiosaefolia. The method comprises the following steps: taking dried Patrinia scabiosaefolia as a raw material, crushing the Patrinia scabiosaefolia, extracting the crushed Patrinia scabiosaefolia with ethanol to obtain an extracting solution, recovering a solvent under reduced pressure to obtain extract, adding water to dissolve the extract, loading a sample on a macroporous resin column, sequentially carrying out gradient elution with 20% ethanol, 40% ethanol, 60% ethanol, 80% ethanol and 95% ethanol, collecting the 40% ethanol eluted part, mixing the 40% ethanol eluted part with silica gel, packing, eluting with dichloromethane-methanol in a volume ratio of 20: 1, carrying out thin-layer chromatography detection, merging the same components, and recovering the solvent under reduced pressure to obtain the product. The method provided by the invention is beneficial to better development and utilization of the Patrinia scabiosaefolia which is a medicinal plant, and is beneficial to sustainable utilization of the plant,the extraction process is simple, the solvent can be recycled, the extraction amountis high, and the method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, in particular to a method of extracting iridoids (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ] decan-4-ol method. Background technique [0002] Huang Hua Pai Jiang ( Patrina scabiosaefolia Fisch.) is the genus Patridae (Valerianaceae) ( Patrinia Juss . )plant. Huang Hua Pai Jiang has the effects of clearing heat and detoxifying, breaking blood stasis and draining pus, and can be used to treat intestinal abscess, lung abscess, dysentery, postpartum stasis abdominal pain, etc. [0003] The natural compound (4) involved in the present invention β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ]Decan-4-ol is first extracted and isolated from Patrinia chinensis, and belongs to a kind of iridoid compounds. (4 β , 8 β )-8-methoxy-3-methyl-10-methenyl-2, 9-dioxetane[4.3.1.0 3,7 ] The source of decan-4-ol is mainly concentrated in the P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08
CPCC07B2200/07C07D493/08
Inventor 刘振花康文艺马常阳崔丽丽蒙丽君王莉屈娇娇
Owner HENAN UNIVERSITY
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