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Gingko protein-derived ACE inhibitory peptide composition as well as preparation method and application thereof

A technology of ginkgo protein and inhibitory peptide, applied in the field of food and medicine, can solve problems such as products with no commercial development of blood pressure lowering effect, and achieve the effect of high safety

Active Publication Date: 2021-03-05
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on ACE inhibitory peptides derived from ginkgo protein is still in its infancy. At present, there are few research reports, and it only stays in simple hydrolysis conditions to explore, and there is no commercial development of products with hypotensive effect.

Method used

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  • Gingko protein-derived ACE inhibitory peptide composition as well as preparation method and application thereof
  • Gingko protein-derived ACE inhibitory peptide composition as well as preparation method and application thereof
  • Gingko protein-derived ACE inhibitory peptide composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The preparation of embodiment 1 ginkgo protein source ACE inhibitory peptide composition

[0054] One, the preparation of defatted ginkgo ginkgo powder

[0055] After the ginkgo is shelled and the membranous endocarp is removed, the ginkgo is placed in a freeze dryer and freeze-dried for 24-48 hours, the dried ginkgo is ground in a high-speed pulverizer, and the ginkgo powder is obtained after sieving.

[0056] Ginkgo powder and petroleum ether are fully mixed at a ratio of 1:12 (mass and volume), placed at 0-4°C, stirred once every 1-2h, and petroleum ether is replaced after 4-6h. After repeating 3-4 times, Until the ginkgo powder is white, then the ginkgo powder and petroleum ether are separated to collect the wet ginkgo powder. Finally, in a ventilation system, under normal temperature conditions, until the petroleum ether is completely volatilized, the defatted ginkgo powder is prepared.

[0057] Two, the preparation of ginkgo protein

[0058] Dissolve defatted g...

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Abstract

The invention discloses a gingko protein-derived ACE inhibitory peptide composition as well as a preparation method and application thereof, and belongs to the technical field of food medicines. The gingko protein-derived ACE inhibitory peptide composition is mainly composed of six small molecule peptides with amino acid sequences of GFDGR, NDPGR, LDQTYRP, REHETIIL, LRMPGPPSSDDY and LRMPGPPSDDYER.The specific preparation process comprises the following steps: preparing gingko protein, hydrolyzing the gingko protein, performing enzymolysis hydrolysis on the gingko protein to obtain an ACE inhibitory peptide crude product, and separating and purifying the gingko protein-derived ACE inhibitory peptide composition. The gingko protein source ACE inhibitory peptide composition is produced by utilizing a biological enzyme technology, the ACE inhibitory activity is taken as a detection index, the technological process and technological parameters for producing the gingko protein source ACE inhibitory peptide composition by utilizing the biological enzyme technology are established, and theoretical basis and technical support are provided for industrial production.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to a ginkgo protein source ACE inhibitory peptide composition and its preparation method and application. Background technique [0002] Hypertension is a chronic disease that is extremely harmful to human health. It is the main controllable risk factor for cardiovascular and cerebrovascular diseases such as coronary heart disease and stroke. The research results show that a 5mmHg reduction in blood pressure is equivalent to a 16% reduction in the risk of cardiovascular and cerebrovascular diseases. Currently, the first-line drugs used to treat hypertension mainly include: diuretics, receptor blockers, angiotensin-converting enzyme inhibitors, Calcium channel blockers, receptor blockers, angiotensin receptor antagonists and other six categories. Hundreds of billions of dollars are spent on antihypertensive drugs worldwide every year. At the same time, various side effects...

Claims

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Application Information

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IPC IPC(8): C07K7/06C07K7/08C12P21/06C12P21/02C07K1/34C07K1/20C07K1/16C07K1/36G01N33/68A61K38/10A61P9/12A61K38/08
CPCC07K7/06C07K7/08C12P21/06C12P21/02G01N33/6848A61K38/10A61K38/08A61P9/12A61K2300/00A61K38/00C07K14/415A61K38/168
Inventor 侯俊财姜瞻梅钱珊珊高懿彤李金哲
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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