Bioactive scaffold for controlling multistage release of drugs and manufacturing method of bioactive scaffold

A bioactive, porous scaffold technology, applied in the fields of manufacturing tools, additive manufacturing, tissue regeneration, etc., can solve the problems that small and short bone defects are not suitable, cannot use liquid drugs, and is difficult to cooperate with application, etc., to promote the self-healing of bone injury. , The effect of promoting bone self-healing and excellent self-healing effect

Active Publication Date: 2021-03-09
HANGZHOU DIANZI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The utility model patent with the authorized notification number CN 210096010 U discloses a porous bone scaffold, which is composed of bioactive additives, degradable metals, and has multiple holes on the scaffold. The porous scaffold invented by this technology is beneficial to the growth of bone tissue cells. Growth, in whi...

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  • Bioactive scaffold for controlling multistage release of drugs and manufacturing method of bioactive scaffold
  • Bioactive scaffold for controlling multistage release of drugs and manufacturing method of bioactive scaffold
  • Bioactive scaffold for controlling multistage release of drugs and manufacturing method of bioactive scaffold

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Embodiment

[0057] The bioactive stent for controlling the multi-stage release of drugs manufactured in this embodiment, for the selected materials, the outer stent, the inner unit and the outer stent protective layer adopt hydroxyapatite, and the drug loading in the inner unit is bisphosphonate and alprostadil , see the specific process figure 1 .

[0058] 1) Mix the required hydroxyapatite powder with the hydrogel solution at a ratio of 3:2 to obtain a high-viscosity bioink.

[0059] 2) The bio-ink is added to the 3D printer, and the external support model is designed. Considering the shrinkage after sintering, the cross-section of the frame is a square of 10mm, and the thickness between the units is 1mm. Use a 3D printer to manufacture the outer bracket, and get the outer bracket blank, clean the outer bracket blank, and then dry it in an oven at 80 degrees Celsius for 6 hours, put the outer bracket in a high-temperature furnace for high-temperature calcination, and burn it at 1200 de...

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Abstract

The invention discloses a bioactive scaffold for controlling multistage release of drugs and a manufacturing method of the bioactive scaffold. The scaffold is composed of two or more than two different scaffold units, each scaffold unit comprises an external scaffold, an external scaffold protective layer and an internal unit located in the external scaffold; each internal unit is composed of a shell, a porous scaffold wrapping the shell and drugs distributed in the shell and the porous scaffold; the pore diameter of each porous scaffold is 100-500 microns; and the outer scaffolds, the protective layers, the porous scaffolds and the shell are all made of bioactive materials. Various drugs required by bone self-healing can be carried into all the internal units, the release time of each drug is accurately controlled, the multistage release of the drugs in different time periods is realized, and the effects of each drug in different bone self-healing stages are fully exerted, so that thebone can be more effectively and quickly self-healed.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a bioactive scaffold for controlling drug multi-stage release and a manufacturing method thereof. Background technique [0002] For a long time, the rapid regeneration and repair of bone defects has been a hot spot in related fields, and it is also a difficult problem in clinical medicine. For the treatment of bone injuries, we are always looking for faster and better methods. In the past, people mainly used metals, alloys or biologically inert ceramic artificial materials with high mechanical strength to repair, fill and replace human bone defects, but these fillers only played the role of mechanical support. With the development of science and technology, these materials can no longer meet the needs of medical development. People have begun to study degradable biomaterials, which have excellent mechanical properties and good biological activity. They can also promot...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/50A61L27/54A61L27/56A61L27/58A61F2/28A61F2/30B33Y80/00
CPCA61L27/12A61L27/025A61L27/56A61L27/50A61L27/54A61L27/58A61F2/28A61F2/30771A61F2/30942B33Y80/00A61L2300/112A61L2300/22A61L2300/412A61L2300/604A61L2430/02A61F2002/30329A61F2002/30784A61F2002/30985
Inventor 邵惠锋年志恒贺永段王平景卓荦龚友平刘海强陈慧鹏李文欣
Owner HANGZHOU DIANZI UNIV
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