Method for preparing oxidized chitosan and derivatives thereof by electrolytic method

A technology for oxidizing chitosan and its derivatives, which is applied in the field of biomedical materials, can solve the problems of no oxidized chitosan and its derivatives, and achieve the effects of saving manufacturing costs, less dosage, and lower prices

Inactive Publication Date: 2021-03-09
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of electrolysis, it is currently only used to oxidize starch, and there is no report on the preparation of oxidized chitosan and its derivatives by electrolysis.

Method used

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  • Method for preparing oxidized chitosan and derivatives thereof by electrolytic method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Add 200ml of dilute sulfuric acid solution with a concentration of 0.3mol / L in the anode tank of the electrolytic cell, weigh 0.25 grams of sodium iodate, add it to the anode tank, and stir to make it dissolve completely;

[0039] (2) Weigh 4 grams of chitosan, add it to the anode tank, and stir to dissolve it completely;

[0040] (3) Add 300ml of dilute sulfuric acid with a concentration of 0.15mol / L to the cathode tank of the electrolytic cell;

[0041] (4) Turn on the DC power supply, set the current to 1.0A, control the temperature at 50°C, and react for 3 hours in the dark;

[0042] (5) Add 200ml of absolute ethanol, collect the precipitate, and collect the waste liquid;

[0043] (6) Pour the precipitate into a dialysis bag with a molecular weight cut-off of 8000Da, place the dialysis bag in 500ml of distilled water, dialyze for 12 hours, and collect the distilled water after the first dialysis;

[0044] (7) Place the dialysis bag in 1500ml of distilled water, ...

Embodiment 2

[0051] (1) Add 100ml of dilute sulfuric acid solution with a concentration of 0.2mol / L in the anode tank of the electrolytic cell, weigh 0.5 grams of sodium iodate, add it to the anode tank, and stir to make it dissolve completely;

[0052] (2) Weigh 10 grams of chitosan oligosaccharide, add it to the anode tank, and stir to dissolve it completely;

[0053] (3) Add 250ml of dilute sulfuric acid with a concentration of 0.3mol / L to the cathode tank of the electrolytic cell;

[0054] (4) Turn on the DC power supply, set the current to 1.5A, control the temperature at 16°C, and react for 2 hours in the dark;

[0055] (5) Pour the reactant into a dialysis bag with a molecular weight cut-off of 500Da, place the dialysis bag in 1500ml of distilled water, change the distilled water every 12 hours, and dialyze for 24 hours;

[0056] (6) Take out the product in the dialysis bag, and use freeze-drying to obtain oxidized chitosan oligosaccharide;

[0057] In this example, the platinum s...

Embodiment 3

[0059] (1) Add 300ml of dilute sulfuric acid solution with a concentration of 0.15mol / L to the anode tank of the electrolytic cell, weigh 1 g of sodium iodate, add it to the anode tank, and stir to dissolve it completely;

[0060] (2) Weigh 10 grams of chitosan diquaternary ammonium salt, add it to the anode tank, and stir to dissolve it completely;

[0061] (3) Add 200ml of dilute sulfuric acid with a concentration of 0.2mol / L to the cathode tank of the electrolytic cell;

[0062] (4) Turn on the DC power supply, set the current to 0.6A, control the temperature at 5°C, and react for 5.0 hours under dark conditions;

[0063] (5) Pour the reactants into a dialysis bag with a molecular weight cut-off of 3000Da, place the dialysis bag in 500ml of distilled water for 12 hours, and collect the dialyzed distilled water;

[0064] (6) Place the dialysis bag in 2000ml of distilled water for 12 hours and change the distilled water every 12 hours for 48 hours;

[0065] (7) Take out the...

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Abstract

The invention discloses a method for preparing oxidized chitosan and derivatives thereof by an electrolytic method. According to the method, a small amount of sodium iodate is adopted in an electrolytic tank to selectively oxidize chitosan and derivatives thereof under a dark condition, and after dialysis separation, oxidized chitosan containing aldehyde groups with high chemical reaction activityand derivatives thereof are obtained. Compared with a traditional method, the method has the advantages of being small in oxidant dosage, controllable in oxidation degree, green and environmentally friendly, and is a novel environmentally-friendly preparation method of oxidized chitosan and derivatives thereof.

Description

technical field [0001] The invention relates to a method for preparing oxidized chitosan and its derivatives by electrolysis, which is applied in the field of biomedical materials. Background technique [0002] Biomaterials often require the use of cross-linking agents to reduce immunogenicity, improve physical and mechanical properties, and increase resistance to degradation. At present, oxidized polysaccharides have begun to be used in the cross-linking of biological materials. Sodium periodate is often used as an oxidant in its preparation to selectively oxidize polysaccharides containing adjacent dihydroxyl structures to generate aldehyde groups with strong reactivity. Control the molar ratio of sodium periodate to polysaccharide to control the degree of oxidation to obtain oxidized polysaccharides with different aldehyde content. Meng Shu used sodium periodate to oxidize cellulose, prepared oxidized cellulose, and studied its adsorption effect on urea (Meng Xianshu. Sy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/003
Inventor 但年华但卫华冯荣欣
Owner SICHUAN UNIV
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