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Ibuprofen suspension and preparation method thereof

A technology of suspension and aqueous solution, applied in the field of medicine, can solve the problems of low dissolution rate and poor bioavailability, and achieve the effect of high dissolution rate

Active Publication Date: 2021-03-19
太阳升(亳州)生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because ibuprofen is poorly soluble in water, current ibuprofen suspensions on the market suffer from low dissolution rate, which may lead to relatively poor bioavailability

Method used

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  • Ibuprofen suspension and preparation method thereof
  • Ibuprofen suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh 1620.0g of purified water and pour it into the liquid mixing tank I, heat it to about 100°C while stirring, the stirring speed is 60HZ (3600rpm), add 104.8g of soluble starch, stir for 20min to dissolve completely. Cool down to 40-50°C, add 800.0g glycerin, 17.6g anhydrous citric acid, 6.4g polysorbate 80 and 16.0g sodium benzoate in sequence, wash the remaining material in the beaker with an appropriate amount of purified water, stir for 20 minutes, and dissolve completely.

[0038] Slowly add the prescription amount of 80% sucrose (2400*0.8=1920g), continue to stir for 20min after adding, stir until completely dissolved, then add 160g ibuprofen (D90=45.0μm), 0.176g sunset yellow, 0.016g allura red, Stirring was continued for 40 min.

[0039] Weigh 2430g of purified water and pour it into the liquid mixing tank II, add the remaining 20% ​​sucrose (2400*0.2=480g) and 28.8g xanthan gum (mixed manually for 10min), stir for 30min until the sucrose is completely disso...

Embodiment 2

[0043] Weigh 1620.0g of purified water and pour it into the liquid mixing tank I, heat it to about 100°C while stirring, the stirring speed is 60HZ (3600rpm), add 104.8g of soluble starch, stir for 20min to dissolve completely. Cool down to 40-50°C, add 800.0g glycerin, 17.6g anhydrous citric acid, 6.4g polysorbate 80 and 16.0g sodium benzoate in sequence, wash the remaining material in the beaker with an appropriate amount of purified water, stir for 20 minutes, and dissolve completely.

[0044] Slowly add the prescription amount of 80% sucrose (2400*0.8=1920g), continue to stir for 20min after adding, stir until completely dissolved, then add 160g ibuprofen (D90=50.0μm), 0.176g sunset yellow, 0.016g allura red, Stirring was continued for 40 min.

[0045] Weigh 2430g of purified water and pour it into the liquid mixing tank II, add the remaining 20% ​​sucrose (2400*0.2=480g) and 28.8g xanthan gum (mixed manually for 10min), stir for 30min until the sucrose is completely disso...

Embodiment 3

[0049] Weigh 1620.0g of purified water and pour it into the liquid mixing tank I, heat it to about 100°C while stirring, the stirring speed is 60HZ (3600rpm), add 104.8g of soluble starch, stir for 20min to dissolve completely. Cool down to 40-50°C, add 800.0g glycerin, 17.6g anhydrous citric acid, 6.4g polysorbate 80 and 16.0g sodium benzoate in sequence, wash the remaining material in the beaker with an appropriate amount of purified water, stir for 20 minutes, and dissolve completely.

[0050] Slowly add the prescription amount of 80% sucrose (2400*0.8=1920g), continue to stir for 20min after adding, stir until completely dissolved, then add 160g ibuprofen (D90=65.0μm), 0.176g sunset yellow, 0.016g allura red, Stirring was continued for 40 min.

[0051] Weigh 2430g of purified water and pour it into the liquid mixing tank II, add the remaining 20% ​​sucrose (2400*0.2=480g) and 28.8g xanthan gum (mixed manually for 10min), stir for 30min until the sucrose is completely disso...

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Abstract

An ibuprofen suspension comprises a prescribed amount of ibuprofen, xanthan gum, glycerol, soluble starch, sucrose, anhydrous citric acid, polysorbate, sodium benzoate, allura red, sunset yellow, orange-flavored essence, strawberry essence and purified water, wherein the ibuprofen has a particle size in the range of 35-65 [mu]m. The ibuprofen suspension has a higher dissolution rate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ibuprofen suspension and a preparation method thereof. Background technique [0002] Ibuprofen, also known as ibuprofen, has anti-inflammatory, analgesic and antipyretic effects. Ibuprofen is suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and neuritis. [0003] Since the advent of ibuprofen, it has been favored by consumers because of its anti-inflammatory, pain-relieving and antipyretic effects, which are far superior to aspirin, phenylbutazone and paracetamol. After widely entering the family, ibuprofen has made a huge contribution to relieving the head and body pain caused by patients' joint pain, neuralgia, dysmenorrhea and other diseases. According to the usage data of ibuprofen, the sales volume of ibuprofen is about double that of similar antipyretic and analgesic drugs. [0004] At presen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/192A61K47/10A61K47/12A61K47/26A61K47/36A61P29/00
CPCA61K31/192A61K9/10A61K47/36A61K47/26A61K47/10A61K47/12A61P29/00
Inventor 方小东郭鸿旭
Owner 太阳升(亳州)生物医药科技有限公司
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