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Metal phthalocyanine loaded fluorescent carbon quantum dot as well as preparation method and application thereof

A carbon quantum dot and metal phthalocyanine technology, applied in the field of fluorescent probes, can solve problems such as low accuracy and complicated operation, and achieve the effects of fast response, simple operation, and cheap raw materials

Active Publication Date: 2021-03-26
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application, so as to solve the technical problems of complex operation and low accuracy in the existing catecholamine detection method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation method of zinc phthalocyanine-supported carbon quantum dots

[0029] 1) Slowly add 2 mL of TiCl dropwise to 25 mL of 0.1 g / mL glucose solution under stirring 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 180 °C for 36 hours, and cooled to room temperature to obtain titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0030] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.05 mL of ethylenediamine, mix evenly, seal it and place it in an oven at 180 °C for 6 h, and cool to room temperature to obtain amino-modified Fluorescent carbon quantum dots (N-CQDs) suspension.

[0031]3) Mix 5 mL of N-CQDs suspension with 2.5 mL of DMF solution containing 0.25 mg of acyl chloride zinc phthalocyanine, stir at 40°C for 5 hours, let stand, dialyze the clear solution and freeze-dry to obtain zinc phthalocyanine Cyanine-supported carbon quantum dots ZnPc-CQDs....

Embodiment 2

[0035] 1. Preparation method of copper phthalocyanine-supported carbon quantum dots

[0036] 1) Slowly add 2.5 mL TiCl dropwise to 25 mL 0.1 g / mL sucrose solution under stirring 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 190 °C for 24 hours, and cooled to room temperature to obtain a titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0037] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.08 mL of ethylenediamine, mix evenly, seal it and place it in an oven at 190°C for 5 h, and cool to room temperature to obtain amino-modified Fluorescent carbon quantum dots (N-CQDs) suspension.

[0038] 3) Mix 5 mL of N-CQDs suspension with 2.5 mL of DMF solution containing 0.35 mg of acyl chloride copper phthalocyanine, stir at 40°C for 6 hours, let it stand, dialyze the clear solution and freeze-dry to obtain copper phthalocyanine Cyanine-supported carbon quantum dots CuP...

Embodiment 3

[0042] 1. Preparation method of cobalt phthalocyanine-supported carbon quantum dots

[0043] 1) Slowly add 1.8 mL TiCl dropwise to 25 mL 0.1 g / mL chitosan solution under stirring condition 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 200 °C for 12 hours, and cooled to room temperature to obtain titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0044] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.08 mL of diethylenetriamine, mix well, seal it and place it in an oven at 200°C for 4 h, cool to room temperature, and obtain amino Modified fluorescent carbon quantum dots (N-CQDs) suspension.

[0045] 3) Mix 5 mL N-CQDs suspension with 2.5 mL DMF solution containing 0.5 mg acyl chloride cobalt phthalocyanine, stir at 60 °C for 6 hours, let it stand, and dialyze the clear solution and freeze-dry to obtain cobalt phthalocyanine Cyanine-supported carbon quantum dots ...

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Abstract

The invention discloses a metal phthalocyanine loaded fluorescent carbon quantum dot as well as a preparation method and application thereof, and the preparation method comprises the following steps:firstly, preparing fluorescent carbon quantum dots (CQDs) and metal phthalocyanine (MPc) with a catalytic function by adopting a nano-synthesis technology, and then realizing effective loading of theCQDs and the MPc by adopting an organic-inorganic nano-composite technology to prepare the loaded carbon quantum dot. According to the invention, metal phthalocyanine with a catalytic function and a fluorescence signal sensing group carbon quantum dot are integrated, when the loaded carbon quantum dot catalyzes catecholamine oxidation, an electron transfer channel between CQDs and MPc is destroyed, and fluorescence of the carbon quantum dot is turned on, so that catecholamine catalysis and detection are carried out at the same time. The method has the advantages of being convenient to use andoperate, high in anti-interference capacity, sensitive and reliable in result, low in detection limit, high in response speed and good in stability, real-time online rapid and specific detection can be achieved, and good application prospects and potential application value are achieved.

Description

technical field [0001] The invention relates to the technical field of fluorescent probes, in particular to a metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application. Background technique [0002] Catecholamines are a class of neurological substances containing catechol and amine groups, including epinephrine, norepinephrine, and dopamine. The molecules contain catechol and amine groups, which have important physiological functions. The level of catecholamines in body fluids reflects If the content of adrenaline is too high, it may cause high blood pressure, coronary heart disease, etc., and if the content is too low, it will cause diseases such as hypoglycemia. Early diagnosis and treatment of heart disease, Parkinson's disease, myocardial infarction and other common diseases are of great significance. [0003] At present, a large number of methods for the detection of catecholamines have been reported in the literature, mainly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/22C09K11/06C09K11/65B82Y20/00B82Y30/00B82Y40/00G01N21/64
CPCC07D487/22C09K11/06C09K11/65B82Y20/00B82Y30/00B82Y40/00G01N21/6428C09K2211/188C09K2211/187G01N2021/6432C07B2200/11
Inventor 李明田汪茜贾宇附青山肖丽丽
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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