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A metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application

A carbon quantum dot and metal phthalocyanine technology, applied in the field of fluorescent probes, can solve problems such as low accuracy and complicated operation, and achieve fast response, simple operation and obvious effect

Active Publication Date: 2022-03-08
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application, so as to solve the technical problems of complex operation and low accuracy in the existing catecholamine detection method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Preparation method of zinc phthalocyanine-supported carbon quantum dots

[0029] 1) Slowly add 2 mL of TiCl dropwise to 25 mL of 0.1 g / mL glucose solution under stirring 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 180 °C for 36 hours, and cooled to room temperature to obtain titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0030] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.05 mL of ethylenediamine, mix well, seal it and place it in an oven at 180 °C for 6 h, cool to room temperature, and obtain amino-modified Fluorescent carbon quantum dots (N-CQDs) suspension.

[0031]3) Mix 5 mL of N-CQDs suspension with 2.5 mL of DMF solution containing 0.25 mg of acyl chloride zinc phthalocyanine, stir at 40°C for 5 hours, let stand, dialyze the clear solution and freeze-dry to obtain zinc phthalocyanine Cyanine-supported carbon quantum dots ZnPc-CQDs.

...

Embodiment 2

[0035] 1. Preparation method of copper phthalocyanine-supported carbon quantum dots

[0036] 1) Slowly add 2.5 mL TiCl dropwise to 25 mL 0.1 g / mL sucrose solution under stirring 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 190 °C for 24 hours, and cooled to room temperature to obtain a titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0037] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.08 mL of ethylenediamine, mix evenly, seal it and place it in an oven at 190°C for 5 h, and cool to room temperature to obtain amino-modified Fluorescent carbon quantum dots (N-CQDs) suspension.

[0038] 3) Mix 5 mL of N-CQDs suspension with 2.5 mL of DMF solution containing 0.35 mg of acyl chloride copper phthalocyanine, stir at 40°C for 6 hours, let it stand, dialyze the clear solution and freeze-dry to obtain copper phthalocyanine Cyanine-supported carbon quantum dots CuP...

Embodiment 3

[0042] 1. Preparation method of cobalt phthalocyanine-supported carbon quantum dots

[0043] 1) Slowly add 1.8 mL TiCl dropwise to 25 mL 0.1 g / mL chitosan solution under stirring condition 3 The solution was mixed evenly and transferred to a 50 mL polytetrafluoroethylene reactor, sealed at 200 °C for 12 hours, and cooled to room temperature to obtain titanium-doped carbon quantum dot suspension (Ti-CQDs).

[0044] 2) Take 10 mL of Ti-CQDs suspension and place it in a polytetrafluoroethylene reaction kettle, add 0.08 mL of diethylenetriamine, mix well, seal it and place it in an oven at 200°C for 4 h, cool to room temperature, and obtain amino Modified fluorescent carbon quantum dots (N-CQDs) suspension.

[0045] 3) Mix 5 mL N-CQDs suspension with 2.5 mL DMF solution containing 0.5 mg acyl chloride cobalt phthalocyanine, stir at 60 °C for 6 hours, let it stand, and dialyze the clear solution and freeze-dry to obtain cobalt phthalocyanine Cyanine-supported carbon quantum dots ...

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Abstract

The invention discloses a metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application. First, fluorescent carbon quantum dots (CQDs) and metal phthalocyanine (MPc) with catalytic function are prepared by nano-synthesis technology, and then organic- Inorganic nanocomposite technology realizes the effective loading of CQDs and MPc to prepare the loaded carbon quantum dots. The invention integrates the metal phthalocyanine with catalytic function and the carbon quantum dot of the fluorescent signal induction group. When the loaded carbon quantum dot catalyzes the oxidation of catecholamine, the electron transfer channel between CQDs and MPc is destroyed, and the carbon quantum dot Fluorescence is "turned on" allowing simultaneous catalysis and detection of catecholamines. The method has the advantages of convenient operation, strong anti-interference ability, sensitive and reliable results, low detection limit, fast response speed, and good stability. It can realize fast and specific detection on-line in real time, and has good application prospects and potential Value.

Description

technical field [0001] The invention relates to the technical field of fluorescent probes, in particular to a metal phthalocyanine-loaded fluorescent carbon quantum dot and its preparation method and application. Background technique [0002] Catecholamines are a class of neurological substances containing catechol and amine groups, including epinephrine, norepinephrine, and dopamine. The molecules contain catechol and amine groups, which have important physiological functions. The level of catecholamines in body fluids reflects If the content of adrenaline is too high, it may cause high blood pressure, coronary heart disease, etc., and if the content is too low, it will cause diseases such as hypoglycemia. Early diagnosis and treatment of heart disease, Parkinson's disease, myocardial infarction and other common diseases are of great significance. [0003] At present, a large number of methods for the detection of catecholamines have been reported in the literature, mainly...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/22C09K11/06C09K11/65B82Y20/00B82Y30/00B82Y40/00G01N21/64
CPCC07D487/22C09K11/06C09K11/65B82Y20/00B82Y30/00B82Y40/00G01N21/6428C09K2211/188C09K2211/187G01N2021/6432C07B2200/11
Inventor 李明田汪茜贾宇附青山肖丽丽
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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