Application of bupleurum tenuifolium extract in treatment of viral pneumonia

A technology of Bupleurum edulis extract and viral pneumonia, applied in the application field of Xiao Bupleurum extract in the treatment of viral pneumonia, can solve the problems of high price, large side effects, poor curative effect and the like

Pending Publication Date: 2021-03-30
BEIJING HANDIAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no specific antiviral drug for viral pneumonia. Recognized antiviral drugs such as ribavirin, acyclovir, ganciclovir, etc. limited use

Method used

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  • Application of bupleurum tenuifolium extract in treatment of viral pneumonia
  • Application of bupleurum tenuifolium extract in treatment of viral pneumonia
  • Application of bupleurum tenuifolium extract in treatment of viral pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] This embodiment provides the preparation method of Xiaobupleurum granule, which is made of the following traditional Chinese medicine components in parts by weight: 240g of Bupleurum, 90g of Jiang Pinellia, 90g of Scutellaria baicalensis, 90g of Codonopsis pilosula, 90g of licorice, 90g of ginger and 90g of jujube ;

[0038] Its preparation method comprises the following steps:

[0039] Step 1: prepare the bulk drug according to the weight parts.

[0040] Step 2: Take the five flavors of Bupleurum, Scutellaria, Codonopsis, Licorice, and Jujube, add 12 times of water, decoct twice for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to an appropriate amount.

[0041] Step 3: Use 70% ethanol as a solvent for ginger pinellia and ginger. After soaking for 24 hours, slowly percolate at a rate of 1-3ml per minute. Collect about 900ml of filtrate, recover ethanol, and concentrate to an appropriate amount.

[0042] Step 4: Combine the concentrat...

experiment example 1

[0044] Pharmacodynamic experiment of Xiao Bupleurum extract against influenza A virus pneumonia

[0045] (1) Experimental materials:

[0046] Test drug: Xiaobupleurum granule (provided by Example 1); positive control drug (ribavirin granule, Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd., batch number H20044779). Animals: Balb / c mice, male and female, 13-15g. Influenza A H1N1 virus: Provided by the Institute of Virology, Chinese Academy of Preventive Medicine.

[0047] (2) Experimental method:

[0048] Balb / c mice were randomly divided into 6 groups, 10 in each group, respectively normal control group, virus control group, high (4.5g / kg), medium (2.25g / kg) and low (1.13g / kg) of test drugs. kg) three dose groups and the positive control drug ribavirin granule group. In addition to the normal control group, the mice were lightly anesthetized with ether and infected with 15LD by intranasal drip. 50 Influenza A H1N1 virus. After infection, administration or normal saline ...

experiment example 2

[0057] Pharmacodynamic experiment of Xiao Bupleurum extract against human rhinovirus pneumonia

[0058] (1) Experimental materials:

[0059] Test drug: Xiaobupleurum granule (provided by Example 1); positive control drug (ribavirin granule, Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd., batch number H20044779). Animals: Balb / c mice, male and female, 13-15g. Human rhinovirus: Provided by the Institute of Virology, Chinese Academy of Preventive Medicine.

[0060] (2) Experimental method:

[0061] Balb / c mice were randomly divided into 6 groups, 10 in each group, respectively normal control group, virus control group, high (4.5g / kg), medium (2.25g / kg) and low (1.13g / kg) of test drugs. kg) three dose groups and the positive control drug ribavirin granule group. In addition to the normal control group, the mice were lightly anesthetized with ether and infected with 15LD by intranasal drip. 50 Human rhinovirus. After infection, administration or normal saline was started, ...

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Abstract

The invention discloses application of a bupleurum chinense extract in treatment of viral pneumonia, and relates to the technical field of traditional Chinese medicines. The invention discloses application of the bupleurum chinense extract in preparation of a medicine for treating viral pneumonia. The bupleurum tenuifolium extract has a relatively strong inhibition effect on viruses, has a lower usage amount, can be used for treating pneumonia caused by influenza A viruses, human rhinoviruses, human adenoviruses, common coronaviruses, coxsackie viruses or parainfluenza viruses, and is ineffective to viral pneumonia caused by herpes simplex viruses and human metapneumoviruses. A new strategy is provided for treating viral pneumonia.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the application of the extract of Radix Bupleurum in the treatment of viral pneumonia. Background technique [0002] Xiaochaihu Granules, the prescription comes from the "Standards of the State Food and Drug Administration (Trial)", which is composed of seven Chinese medicinal materials including Bupleurum, Ginger Pinellia, Scutellaria, Codonopsis, Licorice, Ginger, and Jujube. Stomach effect, used for exogenous diseases, evil offender Shaoyang syndrome, symptoms include alternating cold and heat, bitter fullness in the chest and hypochondrium, loss of appetite, upset and vomiting, bitter mouth and dry throat. [0003] Shaoyang Syndrome, one of the six meridian diseases in Treatise on Febrile Diseases. It refers to the pathological changes characterized by bitter mouth, dry throat, dizziness, alternating cold and heat, bitterness in the chest and hypochondri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P11/00A61P31/16A61P31/14A61P31/20
CPCA61K36/233A61K36/8888A61K36/539A61K36/344A61K36/484A61K36/9068A61K36/725A61P11/00A61P31/16A61P31/14A61P31/20A61K2236/331A61K2236/39A61K2236/333A61K2236/51A61K2300/00
Inventor 林德良孙英妮田志浩李鹏
Owner BEIJING HANDIAN PHARMA CO LTD
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