Novel drug application of baricitinib

A technique of tinib and pharmacy, which is applied in the field of medicine and can solve the problem of no reports of endogenous cardiomyocyte proliferation with baricitinib
CN112587530AActive Publication Date: 2021-04-02SYNOGENBIOPHARMACO LTD NANJING CHINA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SYNOGENBIOPHARMACO LTD NANJING CHINA
Publication Date
2021-04-02

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Abstract

The invention discloses a novel drug application of baricitinib. More specifically, the application refers to the application of the baricitinib or pharmaceutically acceptable salt or ester thereof inpreparation of drugs for promoting the proliferation of cardiomyocytes. Experimental results show that the baricitinib can promote the proliferation of the cardiomyocytes of rats. Thus, the baricitinib can be used for the related fields in preparing the drugs for promoting the proliferation of the cardiomyocytes and the drugs for treating or preventing heart diseases; and a novel drug and treatment idea can be provided for treating or preventing the heart diseases such as myocardial infarction.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a new drug application of baricitinib. Background technique

[0002] At present, cardiovascular disease has become the number one killer threatening human health. There are 40 million heart failure patients worldwide, and it has become the main cause of human death. Studies have found that cardiomyocytes in mammals gradually lose their ability to proliferate after adulthood. Once myocardial infarction occurs, the loss of cardiomyocytes will be irreversible. There are about 2-4 billion cardiomyocytes in an adult, about 25% of cardiomyocytes will be lost within a few hours after myocardial infarction, and the remaining cardiomyocytes have very limited proliferation ability, which is not enough to restore the contractile function of the heart, and the patient will eventually suffer from heart failure die. To solve this problem, in addition to surgery, basic translational resear...

Claims

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