Ac-SDKP-LDH nanocrystallization preparation as well as preparation method and application thereof
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A nanotechnology, ac-sdkp-ldh, applied in chemical instruments and methods, alkali metal aluminate/alumina/aluminum hydroxide preparation, inorganic chemistry, etc., to achieve easy operation, enhanced anti-fibrosis, biosafety high sex effect
Active Publication Date: 2021-04-02
复旦大学附属中山医院青浦分院
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In the research of our research group, it is also found that LDH has a good an
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Embodiment 1
[0060] A kind of Ac-SDKP-LDH nano preparation of the present invention comprises LDH and Ac-SDKP inserted between LDH layers, and LDH and Ac-SDKP are combined with each other through ionic bonds; wherein, the weight ratio of LDH and Ac-SDKP is 1 :1.
[0061] The preparation method of the above-mentioned Ac-SDKP-LDH nano preparation comprises the following steps: fully mixing LDH and Ac-SDKP, and then reacting at 4°C for 12 hours, so that Ac-SDKP is inserted into the interlayer of LDH through ion exchange, and Ac-SDKP is obtained. SDKP-LDH nano preparation.
[0062] Application of the above-mentioned Ac-SDKP-LDH nano-formulation preparation in the preparation of anti-silicosis fibrosis drugs.
Embodiment 2
[0064] A kind of Ac-SDKP-LDH nano preparation of the present invention comprises LDH and Ac-SDKP inserted between LDH layers, and LDH and Ac-SDKP are combined with each other through ionic bonds; wherein, the weight ratio of LDH and Ac-SDKP is 1 :5.
[0065] The preparation method of the above-mentioned Ac-SDKP-LDH nano preparation comprises the following steps: fully mixing LDH and Ac-SDKP, and then reacting at 4°C for 12 hours, so that Ac-SDKP is inserted into the interlayer of LDH through ion exchange, and Ac-SDKP is obtained. SDKP-LDH nano preparation.
[0066] Application of the above-mentioned Ac-SDKP-LDH nano-formulation preparation in the preparation of anti-silicosis fibrosis drugs.
Embodiment 3
[0068] A kind of Ac-SDKP-LDH nano preparation of the present invention comprises LDH and Ac-SDKP inserted between LDH layers, and LDH and Ac-SDKP are combined with each other through ionic bonds; wherein, the weight ratio of LDH and Ac-SDKP is 1 :10.
[0069] The preparation method of the above-mentioned Ac-SDKP-LDH nano preparation comprises the following steps: fully mixing LDH and Ac-SDKP, and then reacting at 4°C for 12 hours, so that Ac-SDKP is inserted into the interlayer of LDH through ion exchange, and Ac-SDKP is obtained. SDKP-LDH nano preparation.
[0070] Application of the above-mentioned Ac-SDKP-LDH nano-formulation preparation in the preparation of anti-silicosis fibrosis drugs.
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Abstract
The invention discloses an Ac-SDKP-LDH nanocrystallization preparation as well as a preparation method and application thereof. The Ac-SDKP-LDH nanocrystallization preparation comprises LDH and Ac-SDKP inserted between LDH layers and is prepared through the following steps that the LDH and the Ac-SDKP are fully mixed and react at the temperature of 2-8 DEG C for 8-24 h, the Ac-SDKP is inserted between the LDH layers through ion exchange, and the Ac-SDKP-LDH nanocrystallization preparation is obtained. The Ac-SDKP-LDH nanocrystallization preparation disclosed by the invention can be used for preparing anti-silicofibrosis medicines. The method for preparing the Ac-SDKP-LDH nanocrystallization preparation is simple and easy to operate, and according to the prepared Ac-SDKP-LDH nanocrystallization preparation, under the action of a cell microenvironment, a cationic laminate of LDH dissolves in inorganic metal ions, so that the Ac-SDKP is released, the effect of protecting the Ac-SDKP is achieved, the anti-EMT effect can be sufficiently exerted, and the Ac-SDKP-LDH nanocrystallization preparation is used for preventing and treating silicosis fibrosis and has the medicine controlled release characteristics of long lasting time, high biological safety and pH sensitivity. In addition, the LDH has a certain anti-fibrosis effect, and the anti-fibrosis effect of the LDH is enhanced by compounding the LDH and the Ac-SDKP.
Description
technical field [0001] The invention relates to the technical field of nano-biomedicine, in particular to an Ac-SDKP-LDH nano preparation and its preparation method and application. Background technique [0002] Epithelial-mesenchymal transition (EMT) refers to the process in which epithelial cells gradually lose epithelial phenotypic characteristics and acquire mesenchymal phenotypes, mainly manifested in changes in transcriptional regulation, cell polarity and adhesion , the expression of epithelial cell marker surfactant protein A (SP-A) decreased, while the expression of mesenchymal cell markers α-smooth muscle actin (α-SMA) and vimentin (vimentin) was in contrast. It has been shown in the existing literature that EMT plays a role in the process of organ fibrosis in many animal models of organ fibrosis, such as myocardial infarction, liver damage induced by bile duct ligation, diabetic renal fibrosis, and bleomycin-induced interstitial lung disease. important role. The...
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