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Compound Xueshuantong soft capsule and quality detection method of same

A detection method and thrombus technology, applied in the detection of salvianolic acid B content in Fufang Xueshuantong Soft Capsules and Fufang Xueshuantong Soft Capsules, in the field of quality inspection of Fufang Xueshuantong Soft Capsules and There are problems such as large error in the result and great influence on the measurement result, so as to achieve the effects of high accuracy, uniform content distribution and good product stability.

Pending Publication Date: 2021-04-09
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current detection method for the content of salvianolic acid B in Fufang Xueshuantong soft capsules has a large error in the test results, which has a great impact on the determination results, and its determination needs to be further improved

Method used

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  • Compound Xueshuantong soft capsule and quality detection method of same
  • Compound Xueshuantong soft capsule and quality detection method of same
  • Compound Xueshuantong soft capsule and quality detection method of same

Examples

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preparation example Construction

[0027] The preparation method of Compound Xueshuantong Soft Capsules in the present invention refers to the patent application 201410847417.1 "A Compound Xueshuantong Soft Capsules and Its Preparation Process" proposed by the applicant in 2014. The difference in the present invention is in the preparation steps of the capsule contents, After the notoginseng dry paste powder and the remaining medicinal material dry paste powder are mixed evenly, beeswax, soybean oil and polyethylene glycol 400 are added in proportion by weight, and the polyethylene glycol 400 is not added in the cited patent application documents.

[0028] The present invention also provides a method for detecting the content of salvianolic acid B in the above-mentioned compound Xueshuantong soft capsule, comprising the following steps:

[0029] (1) Preparation of the test solution: take Fufang Xueshuantong soft capsules, pour out the contents, add an organic solvent and carry out ultrasonic treatment, after let...

Embodiment 1

[0037]In this embodiment, a compound Xueshuantong soft capsule comprises the following raw materials in parts by weight: a capsule shell and contents, the contents are composed of effective dry ointment powder, soybean oil, beeswax and polyethylene glycol; The paste powder includes the following medicinal material extracts in parts by weight: 750 parts of Panax notoginseng, 240 parts of Radix Astragali, 150 parts of Salvia miltiorrhiza, and 240 parts of Scrophulariaceae; the weight ratio of the effective dry paste powder to soybean oil is 4:6, and the beeswax The addition ratio is 5 wt% of soybean oil; the capsule shell is made of 1 part of gelatin, 0.4 part of glycerin and 1 part of water in parts by weight. The specification of the prepared compound Xueshuantong soft capsule is 0.74g.

[0038] Further, the addition ratio of the polyethylene glycol is 5-10wt% of soybean oil.

[0039] Further, the polyethylene glycol is polyethylene glycol 400.

[0040] 1 test material

[0...

Embodiment 2

[0078] A compound Xueshuantong soft capsule, comprising the following raw materials in parts by weight: a capsule shell and contents, wherein the contents are composed of effective dry cream powder, soybean oil, beeswax, and polyethylene glycol; effective dry cream powder includes the following weight 600 parts of medicinal material extracts: 600 parts of Panax notoginseng, 200 parts of Radix Astragali, 100 parts of Salvia miltiorrhiza, 200 parts of Scrophulariaceae; the weight ratio of the effective dry paste powder to soybean oil is 3:5, and the addition ratio of the beeswax is soybean oil 4wt%; the capsule shell is made of 0.95 parts by weight of gelatin, 0.3 parts of glycerin and 0.8 parts of water.

[0079] Further, the addition ratio of the polyethylene glycol is 5wt% of soybean oil.

[0080] The rest of the content of this embodiment is the same as that of Embodiment 1, and will not be repeated here.

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Abstract

The invention relates to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a compound Xueshuantong soft capsule and a quality detection method of the same, and especially relates to the compound Xueshuantong soft capsule and the detection method of the content of salvianolic acid B in the compound Xueshuantong soft capsule. The compound Xueshuantong soft capsule comprises a capsule shell and a content, wherein the content is prepared from effective dry extract powder, soybean oil, beewax and polyethylene glycol; the effective dry extract powder is prepared from 600-800 parts of radix notoginseng, 200-300 parts of radix astragali, 100-200 parts of radix salviae miltiorrhizae and 200-300 parts of radix scrophulariae; the weight ratio of the effective dry extract powder to the soybean oil is (3-5):(5-7), and the beewax is added in a proportion of 4-6 percent by weight of the soybean oil. The detection method of the content of salvianolic acid B in the compound Xueshuantong soft capsule comprises the following steps: preparing a test-sample solution, preparing a reference solution and performing determining by adopting high-performance liquid chromatography.

Description

technical field [0001] The invention relates to the technical field of biological extraction, in particular to a method for detecting the quality of Compound Xueshuantong Soft Capsules and Compound Xueshuantong Soft Capsules, in particular to a compound Xueshuantong Soft Capsule and the content of salvianolic acid B in Compound Xueshuantong Soft Capsules detection method. Background technique [0002] At present, cardiovascular and cerebrovascular diseases are a common disease that seriously threatens the health of human beings, especially middle-aged and elderly people over 50 years old. Because cardiovascular and cerebrovascular diseases have the characteristics of sudden onset and ferocious onset, general hard capsules and tablets cannot achieve rapid onset of effect. main dosage form. The content of the current compound Xueshuantong is seriously adsorbed on the capsule shell, which affects the uniformity of the content and affects the content detection, resulting in in...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61K9/48A61K47/44A61K47/10A61K47/42A61P9/00A61P9/10G01N30/02G01N30/06G01N30/74G01N30/86
CPCA61K36/258A61K36/481A61K36/537A61K36/808A61K9/4825A61K9/4808A61K9/4866A61K9/4858A61P9/00A61P9/10G01N30/02G01N30/06G01N30/74G01N30/8634A61K2300/00
Inventor 程小东陈小芳张东梅李渡春
Owner 广东广发制药有限公司