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Ultrasonic administration microbubble compound carrying anti-tumor drug as well as preparation method and application of ultrasonic administration microbubble compound

An anti-tumor drug and compound technology, applied in the field of medicine, can solve the problems of low bioavailability and poor water solubility of anti-tumor drugs

Inactive Publication Date: 2021-04-13
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the defects of poor water solubility and low bioavailability of some anti-tumor drugs, the present invention provides a microbubble complex loaded with anti-tumor drugs

Method used

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  • Ultrasonic administration microbubble compound carrying anti-tumor drug as well as preparation method and application of ultrasonic administration microbubble compound
  • Ultrasonic administration microbubble compound carrying anti-tumor drug as well as preparation method and application of ultrasonic administration microbubble compound
  • Ultrasonic administration microbubble compound carrying anti-tumor drug as well as preparation method and application of ultrasonic administration microbubble compound

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Embodiment 1

[0040] The preparation of embodiment 1, CMBS-GA-PLGA

[0041] 1) Preparation of GA-PLGA nanoparticles and detection of their general properties

[0042] Gambogic acid-loaded nanoparticles were prepared by ultrasonic emulsification and low-temperature vacuum drying technology. The specific operations were as follows: ①Weigh 2g PVA and dissolve it in 50mL DDW, and prepare 4% PVA solution in advance (store at room temperature); ②Prepare an ice box, Weigh 0.05g of PLGA and dissolve it in 1mL of dichloromethane, and put it in a small cillin bottle. After it is completely dissolved, add 0.0025g of DSPC (DSPC:PLGA=1:20), and then add 4mg of gambogic acid; Put on the rubber cover and seal it with a parafilm, put it in a fume hood to let it dissolve naturally; ③Weigh 0.06g NH 4 HCO 3 , dissolved in 1mL DDW, filled in a 2mL EP tube, placed in the above ice box, shaken back and forth to dissolve, and transferred 200 microliters to the above "②" solution with a pipette gun; Solution em...

Embodiment 2

[0055] The performance investigation of embodiment 2, CMBS-GA-PLGA

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Abstract

The invention provides an ultrasonic administration microbubble compound carrying an anti-tumor drug as well as a preparation method and application of the ultrasonic administration microbubble compound. The compound is prepared by connection of cationic microbubbles and an anti-tumor drug-PLGA nanoparticles through attraction of positive and negative charges. According to the preparation method, the GA-PLGA nano-particles are prepared by utilizing an ultrasonic emulsification effect, and the CMB and the GA-PLGA nano-particles are connected through charge attraction to form the CMBS-GA-PLGA micro-bubble compound due to the fact that the cationic micro-bubbles carry positive charges and the GA-PLGA nano-particles carry negative charges. The micro-bubbles generate a series of alternative changes such as expansion, shrinkage, oscillation and implosion under the effect of ultrasound, so that the permeability of a cell membrane is improved, the phenomenon is called as 'sound pore effect', gambogic acid can better act on glioblastoma cells by utilizing the 'sound pore effect' of the micro-bubbles under the action of ultrasound, and a new thought is expected to be provided for treatment of glioma.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an ultrasonically administered microbubble compound loaded with antineoplastic drugs and its preparation method and application. Background technique [0002] Glioblastoma originates from the glial cells of the brain and is the most common intracranial tumor, ranking second among childhood malignancies. In the past 30 years, the incidence of primary malignant brain tumors has been increasing year by year, especially in middle-aged and elderly people [Campos B, Olsen LR, Urup T, et al. A comprehensive profile of recurrent glioblastoma. Oncogene, 2016, 35(45): 5819- 5825]. The annual incidence of glioma in China is 3-6 per 100,000 people, and the annual death toll reaches 30,000, which is extremely high [Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA, 2013, 310(17):1842-50]. At present, the main treatment methods for glioma are surger...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/50A61K31/352A61K45/00A61K47/24A61K47/32A61K47/34A61P35/00
CPCA61K41/0028A61K9/5031A61K9/5026A61K9/5084A61K9/5089A61K45/00A61K31/352A61K47/34A61P35/00A61K2300/00
Inventor 王峰董磊李娜娜王永玲魏茜茜常连生穆容红李昭一林晓霞常靓郭志坤常玉巧孙昌业贾阳阳田香勤
Owner XINXIANG MEDICAL UNIV
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